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Gene Review:

US3 - tegument protein; phosphorylates nuclear...

Bovine herpesvirus 1

Favoreel, H.W. et al.

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Disease relevance of US3

The US3 protein is a viral kinase that is conserved among the Alphaherpesvirinae [1].
Here, we show that US3 of the swine alphaherpesvirus pseudorabies virus causes dramatic alterations in the cytoskeleton, resulting in the formation of long actin- and microtubule-containing cell projections in infected and transfected cells [1].

High impact information on US3

Analyzing the effect of these drugs on intercellular virus spread indicated that the observed US3-induced alterations in the host cytoskeleton are associated with enhanced intercellular virus spread, thereby suggesting a previously undescribed aspect of alphaherpesvirus spread [1].

References

Cytoskeletal rearrangements and cell extensions induced by the US3 kinase of an alphaherpesvirus are associated with enhanced spread. Favoreel, H.W., Van Minnebruggen, G., Adriaensen, D., Nauwynck, H.J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]

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