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Gene Review:

EP402R - CD2 homolog

African swine fever virus

This record was discontinued.

Rodríguez, J.M. et al., Ruiz-Gonzalvo, F. et al.

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Disease relevance of EP402R

This result demonstrates that the protein encoded by EP402R is directly involved in the hemadsorption phenomenon induced by the infection of susceptible cells with African swine fever virus [1].

High impact information on EP402R

The disruption of EP402R, achieved through the replacement of a 354-bp-long fragment from within EP402R by the marker gene lacZ, does not affect the virus growth rate in vitro but abrogates the ability of the virus to induce the adsorption of pig erythrocytes to the surface of infected cells [1].
Transcription of EP402R takes place during the late phase of virus replication [1].
The baculovirus-expressed HA showed hemadsorption and erythrocyte-agglutinating activities characteristic of the CD2 homolog protein induced by the virus in infected macrophages [2].

References

African swine fever virus encodes a CD2 homolog responsible for the adhesion of erythrocytes to infected cells. Rodríguez, J.M., Yáñez, R.J., Almazán, F., Viñuela, E., Rodriguez, J.F. J. Virol. (1993) [Pubmed]
Functional and immunological properties of the baculovirus-expressed hemagglutinin of African swine fever virus. Ruiz-Gonzalvo, F., Rodríguez, F., Escribano, J.M. Virology (1996) [Pubmed]

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