Gene Review:
B119L - pB119L
African swine fever virus
This record was discontinued.
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Disease relevance of B119L
- Protein pB119L of African swine fever virus belongs to the Erv1p/Alrp family of sulfhydryl oxidases and has been described as a late nonstructural protein required for correct virus assembly [1].
High impact information on B119L
- We also show in coimmunoprecipitation experiments that protein pB119L interacts with the viral protein pA151R, which contains a CXXC motif similar to that present in thioredoxins [1].
- To further our knowledge of the function of protein pB119L during the virus life cycle, we have investigated whether this protein possesses sulfhydryl oxidase activity, using a purified recombinant protein [1].
- African swine fever virus pB119L protein is a flavin adenine dinucleotide-linked sulfhydryl oxidase [1].
- Furthermore, protein pB119L contains the cysteines of its active-site motif CXXC, predominantly in an oxidized state, and forms noncovalently bound dimers in infected cells [1].
References
- African swine fever virus pB119L protein is a flavin adenine dinucleotide-linked sulfhydryl oxidase. Rodríguez, I., Redrejo-Rodríguez, M., Rodríguez, J.M., Alejo, A., Salas, J., Salas, M.L. J. Virol. (2006) [Pubmed]
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