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Gene Review:

B318L - prenyltransferase

African swine fever virus

Alejo, A. et al., Alejo, A. et al.

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Disease relevance of B318L

The African swine fever virus prenyltransferase is an integral membrane trans-geranylgeranyl-diphosphate synthase [1].

High impact information on B318L

All-trans-polyprenyl diphosphates containing 3-13 isoprene units are synthesized, which identifies the B318L protein as a trans-prenyltransferase [2].
The gene, designated B318L, is located within the EcoRI B fragment in the central region of the virus genome, and encodes a polypeptide with a predicted molecular weight of 35,904 [2].
Protein B318L presents a colinear arrangement of the four highly conserved regions and the two aspartate-rich motifs characteristic of geranylgeranyl diphosphate synthases, farnesyl diphosphate synthases, and other prenyltransferases [2].

References

The African swine fever virus prenyltransferase is an integral membrane trans-geranylgeranyl-diphosphate synthase. Alejo, A., Andrés, G., Viñuela, E., Salas, M.L. J. Biol. Chem. (1999) [Pubmed]
African swine fever virus trans-prenyltransferase. Alejo, A., Yáñez, R.J., Rodríguez, J.M., Viñuela, E., Salas, M.L. J. Biol. Chem. (1997) [Pubmed]

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