Disease relevance of B438L

• The open reading frame B438L, located within the EcoRI B fragment of the African swine fever virus genome, is predicted to encode a protein of 438 amino acids with a molecular mass of 49.3 kDa [1].
• The B438L gene product has been expressed in Escherichia coli, purified and used as an antigen for antibody production [1].
• Using a recombinant ASFV that inducibly expresses protein pB438L, we have determined that this structural protein is essential for the formation of infectious virus particles [2].

High impact information on B438L

• We have examined the function of the ASFV structural protein pB438L, encoded by gene B438L, in virus morphogenesis [2].
• Generation of Filamentous Instead of Icosahedral Particles by Repression of African Swine Fever Virus Structural Protein pB438L [2].
• We show that protein pB438L associates with membranes during the infection, behaving as an integral membrane protein [2].

Analytical, diagnostic and therapeutic context of B438L

• Northern blot and primer extension analysis showed that B438L is transcribed only at late times during virus infection [1].

References