Gene Review:
P1192R - topoisomerase II
African swine fever virus
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Disease relevance of P1192R
- A gene homologous to topoisomerase II in African swine fever virus [1].
High impact information on P1192R
- Sequencing of this region has revealed a long open reading frame, designated P1192R, encoding a protein of 1192 amino acids, with a predicted molecular weight of 135,543 [1].
- The tree indicates that the ASF virus topoisomerase II gene was present in the virus genome before protozoa, yeasts, and metazoa diverged [1].
- The deduced amino acid sequence of this open reading frame shares significant similarity with topoisomerase II sequences from different sources, with percentages of identity between 23 and 29% [1].
Biological context of P1192R
- Open reading frame P1192R is transcribed late after infection into a 4.6-kb RNA [1].
References
- A gene homologous to topoisomerase II in African swine fever virus. García-Beato, R., Freije, J.M., López-Otín, C., Blasco, R., Viñuela, E., Salas, M.L. Virology (1992) [Pubmed]
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