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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

RepA  -  replication-associated protein

Panicum streak virus

 
 
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Disease relevance of RepA

  • The replication-associated protein (RepA) of Maize streak virus interacts in yeast with retinoblastoma-related protein (RBR), the negative regulator of cell-cycle progression [1].
  • Geminivirus infectivity is thought to depend on interactions between the virus replication-associated proteins Rep or RepA and host retinoblastoma-related proteins (pRBR), which control cell-cycle progression [2].
  • MSV promoter activation by RepA depends on an intact RepA retinoblastoma protein (RB)-binding domain [3].
 

High impact information on RepA

  • We designed a single set of degenerate primers which enables the PCR amplification of an approximately 1300 bp DNA fragment spanning both conserved (the RepA gene) and variable (the long intergenic region and MP gene) portions of these viruses' genomes [4].
  • In the current study, Rep and RepA are examined further for their roles in regulating BeYDV gene expression using a series of replication-incompetent constructs [5].
  • Furthermore, RepA is identified as playing more than one role in this transactivation process [5].

References

 
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