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Gene Review

N  -  nucleocapsid protein

Murine hepatitis virus strain A59

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Disease relevance of N


High impact information on N

  • Colonized mice often had pre-existing MHV antibodies directed against epitopes on the E2 glycoprotein, the E1 glycoprotein, and the nucleocapsid protein [5].
  • The nucleotide sequence of the RNA encoding the nucleocapsid protein of coronavirus MHV-A59 has been determined [2].
  • The carboxy-terminally located C4-N fragment (95 amino acids) induced the most pronounced proliferative response irrespective of whether the lymphocyte culture was derived from immunized or MHV-JHM-infected rats [3].
  • Finally, we noted that four of the five N genes contain an internal open reading frame that potentially encodes a protein of 207 amino acids having a large proportion of basic and hydrophobic residues [1].
  • However, amino acid sequence divergences were found to be clustered in two short segments of N, putative spacer regions that, together, constituted only 11% of the molecule [1].

Anatomical context of N

  • N mRNAs transcribed from SP6 and T7 vectors were translated in a rabbit reticulocyte lysate [6].
  • We established T cell lines specific for the truncated N protein fragments and tested their potential to mediate protection by transfer experiments [3].

Analytical, diagnostic and therapeutic context of N


  1. Sequence comparison of the N genes of five strains of the coronavirus mouse hepatitis virus suggests a three domain structure for the nucleocapsid protein. Parker, M.M., Masters, P.S. Virology (1990) [Pubmed]
  2. Sequence of the nucleocapsid gene from murine coronavirus MHV-A59. Armstrong, J., Smeekens, S., Rottier, P. Nucleic Acids Res. (1983) [Pubmed]
  3. An immunodominant CD4+ T cell site on the nucleocapsid protein of murine coronavirus contributes to protection against encephalomyelitis. Wege, H., Schliephake, A., Körner, H., Flory, E., Wege, H. J. Gen. Virol. (1993) [Pubmed]
  4. RNA-binding proteins of coronavirus MHV: detection of monomeric and multimeric N protein with an RNA overlay-protein blot assay. Robbins, S.G., Frana, M.F., McGowan, J.J., Boyle, J.F., Holmes, K.V. Virology (1986) [Pubmed]
  5. Epitope-specific antibody response to murine hepatitis virus-4 (strain JHM). Talbot, P.J., Salmi, A.A., Knobler, R.L., Buchmeier, M.J. J. Immunol. (1985) [Pubmed]
  6. Localization of an RNA-binding domain in the nucleocapsid protein of the coronavirus mouse hepatitis virus. Masters, P.S. Arch. Virol. (1992) [Pubmed]
  7. Evidence for new transcriptional units encoded at the 3' end of the mouse hepatitis virus genome. Schaad, M.C., Baric, R.S. Virology (1993) [Pubmed]
  8. Specific and quantitative detection of PCR products from Clostridium piliforme, Helicobacter bilis, H. hepaticus, and mouse hepatitis virus infected mouse samples using a newly developed electrochemical DNA chip. Goto, K., Horiuchi, H., Shinohara, H., Motegi, K., Hashimoto, K., Hongo, S., Gemma, N., Hayashimoto, N., Itoh, T., Takakura, A. J. Microbiol. Methods (2007) [Pubmed]
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