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Gene Review: 

gag  -  gag protein

Caprine arthritis encephalitis virus

 
 
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Disease relevance of gag

  • Treatment of infected cells with PD98059, a specific inhibitor of the ERK/MAPK pathway, abolishes visna virus replication, as evidenced by extremely low levels of Gag protein expression and reverse transcriptase activity in culture supernatants [1].
  • The MHC-haplotype influences primary, but not memory, immune responses to an immunodominant peptide containing T- and B-cell epitopes of the caprine arthritis encephalitis virus Gag protein [2].
  • In this report, we describe a short peptide, containing a T helper- and a B-cell epitope, located in the Gag protein of the caprine arthritis encephalitis virus (CAEV) [2].

References

  1. Visna virus-induced activation of MAPK is required for virus replication and correlates with virus-induced neuropathology. Barber, S.A., Bruett, L., Douglass, B.R., Herbst, D.S., Zink, M.C., Clements, J.E. J. Virol. (2002) [Pubmed]
  2. The MHC-haplotype influences primary, but not memory, immune responses to an immunodominant peptide containing T- and B-cell epitopes of the caprine arthritis encephalitis virus Gag protein. Fluri, A., Nenci, C., Zahno, M.L., Vogt, H.R., Charan, S., Busato, A., Pancino, G., Peterhans, E., Obexer-Ruff, G., Bertoni, G. Vaccine (2006) [Pubmed]
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