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Gene Review:

pol - pol protein

Caprine arthritis encephalitis virus

Leroux, C. et al., Lee, T.H. et al., Pyper, J.M. et al., Saltarelli, M. et al.

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Disease relevance of pol

The CAEV genome includes the small open reading frames (ORF) between pol and env which are the hallmarks of the lentivirus genomes [1].
An open reading frame whose 5' end overlaps with the pol gene, but is unrelated to the env gene, has been observed in HTLV-III/LAV and visna virus, both cytopathic mammalian retroviruses [2].
We have recently shown that French small ruminant lentiviruses (SRLV) from sheep are more similar to Caprine Arthritis Encephalitis Virus (CAEV) than to visna maedi virus (VMV) in a conserved region of the pol gene [3].

High impact information on pol

These studies showed homology in the 5' region of the genome encompassing U5 and the gag and pol genes and also in a small region in the env gene [4].
A phylogenetic tree of pol gene sequences confirmed the presence of a novel genotype of SRLV in France [3].
The study of further pol gene sequences from both goats and sheep suggests that viral variants show little or no host species specificity [3].

References

Nucleotide sequence and transcriptional analysis of molecular clones of CAEV which generate infectious virus. Saltarelli, M., Querat, G., Konings, D.A., Vigne, R., Clements, J.E. Virology (1990) [Pubmed]
A new HTLV-III/LAV protein encoded by a gene found in cytopathic retroviruses. Lee, T.H., Coligan, J.E., Allan, J.S., McLane, M.F., Groopman, J.E., Essex, M. Science (1986) [Pubmed]
Genomic heterogeneity of small ruminant lentiviruses: existence of heterogeneous populations in sheep and of the same lentiviral genotypes in sheep and goats. Leroux, C., Chastang, J., Greenland, T., Mornex, J.F. Arch. Virol. (1997) [Pubmed]
Genetic variation among lentiviruses: homology between visna virus and caprine arthritis-encephalitis virus is confined to the 5' gag-pol region and a small portion of the env gene. Pyper, J.M., Clements, J.E., Molineaux, S.M., Narayan, O. J. Virol. (1984) [Pubmed]

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