The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

dsrA  -  serum resistance protein DrsA

Haemophilus ducreyi 35000HP

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of dsrA

  • Previously, we showed that serum resistance in Haemophilus ducreyi type strain 35000HP required expression of the outer membrane protein DsrA because the isogenic dsrA mutant FX517 is highly serum susceptible [1].
  • The dsrA mutant was less virulent than the wild type in both the normal and immune cell-depleted swine models of chancroid infection [2].
 

High impact information on dsrA

  • Killing of dsrA mutants of Haemophilus ducreyi by normal human serum occurs via the classical complement pathway and is initiated by immunoglobulin M binding [1].
  • Finally, we wanted to examine the importance of keratinocyte adhesion in chancroid pathogenesis so we tested the wild-type and dsrA mutant strains of H. ducreyi in our swine models of chancroid pathogenesis [2].
  • When complemented in trans with a plasmid containing dsrA, FX517 is converted to a serum-resistant phenotype (C. Elkins, K. J. Morrow, Jr., and B. Olsen, Infect. Immun. 68:1608-1619, 2000) [3].
  • The dsrA locus from eight additional H. ducreyi strains was sequenced, and the deduced amino acid sequences were more than 85% identical [4].

References

  1. Killing of dsrA mutants of Haemophilus ducreyi by normal human serum occurs via the classical complement pathway and is initiated by immunoglobulin M binding. Abdullah, M., Nepluev, I., Afonina, G., Ram, S., Rice, P., Cade, W., Elkins, C. Infect. Immun. (2005) [Pubmed]
  2. The Haemophilus ducreyi serum resistance antigen DsrA confers attachment to human keratinocytes. Cole, L.E., Kawula, T.H., Toffer, K.L., Elkins, C. Infect. Immun. (2002) [Pubmed]
  3. DsrA-deficient mutant of Haemophilus ducreyi is impaired in its ability to infect human volunteers. Bong, C.T., Throm, R.E., Fortney, K.R., Katz, B.P., Hood, A.F., Elkins, C., Spinola, S.M. Infect. Immun. (2001) [Pubmed]
  4. Serum resistance in Haemophilus ducreyi requires outer membrane protein DsrA. Elkins, C., Morrow, K.J., Olsen, B. Infect. Immun. (2000) [Pubmed]
 
WikiGenes - Universities