Disease relevance of env

• In this study, we compared the abilities of HIV-1 MA mutants to incorporate Env protein complexes with long and short cytoplasmic tails [1].
• Targeted delivery of the chimeric env protein to injured mouse aorta and selective binding of the collagen-targeted virions to injured rabbit artery were observed [2].
• Clones that produced high levels of reverse transcriptase and env protein were tested for their ability to package the replication-defective retrovirus vectors delta neo and N2 [3].
• Analysis of deletion and point mutants of the HFV Env protein revealed that the HFV Env cytoplasmic domain (CyD) is dispensable for HFV particle envelopment, release, and infectivity, whereas deletion of the membrane-spanning-domain (MSD) led to an accumulation of naked capsids in the cytoplasm [4].
• Here we describe heat-directed targeting of an activated form of the Gibbon ape leukemia virus env protein (GALV FMG) to tumor cells [5].

High impact information on env

• The two viruses differed only at amino acid 242 of the polyproline-rich region in the surface (SU) subunit of the Env protein [6].
• In comparative studies, vascular smooth muscle cell transduction was demonstrated in catheter-injured carotid arteries following infusion of collagen-targeted virions but not of virions bearing WT env protein [2].
• Moreover, incorporation of the autologous Env protein complex could be restored by a second-site mutation that resulted in the truncation of the cytoplasmic tail of the HIV-1 transmembrane glycoprotein [1].
• We suggest that the truncated env protein mediates resistance by receptor blockade and that this form of enFeLV expression mediates the natural resistance of cats to infection with FeLV-B in the absence of FeLV-A [7].
• Synchronized mouse cells (JLS-V9) chronically infected with Rauscher murine leukemia virus were used to study virus production, the synthesis of gag and env precursor proteins, and the expression of env protein on the cell surface during the cell cycle [8].

Biological context of env

• Analyses of the kinetics of env protein synthesis and secretion in NRK cells infected with the Lilly-Steeves strain of SFFVp indicated that this product, gp65, was formed rapidly and remained stably associated with cells for up to 4 hr, at which point it was first detected in supernatant medium [9].
• This new system was used to evaluate the contribution of drug-resistance mutations in the pol and env genes to overall viral replicative fitness (in the presence and absence of drug pressure) using direct growth competition experiments [10].
• Serial studies using chimeric viruses derived from the A8-V and the 57 virus (57-V), which is a non-neuropathogenic strain of Friend murine leukemia virus, proved that the long terminal repeat (LTR) and 5' leader (LTR-leader/A8) derived from A8-V, in addition to the env gene (env/A8) of A8-V, are necessary for the neuropathogenesis of A8-V [11].

Associations of env with chemical compounds

• We also determined the site of expression of a chimeric env protein which contains the external domain of SFFV gp52 the transmembrane, and the cytoplasmic tail residues of Friend MuLV [12].
• We postulate that the highly fusogenic property of M813 is attributable to either its unique receptor usage or sequences in the proline-rich domain of the Env protein [13].

References