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Gene Review:

cdtB - cytolethal distending toxin CdtB

Helicobacter hepaticus ATCC 51449

This record was discontinued.

Kostia, S. et al., Ge, Z. et al.

Ge, Feng, Whary, Nambiar, Xu, Ng, Taylor, Fox,

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Disease relevance of cdtB

Our results are in accordance with previous observations that the cdtB gene is not present in all Helicobacter species [1].

High impact information on cdtB

A cdtB-deficient H. hepaticus isogenic mutant (HhcdtBm7) was generated and characterized for colonization parameters in four intestinal regions (jejunum, ileum, cecum, and colon) of outbred Swiss Webster (SW) mice [2].
The cdtB-positive strains had effects ranging from weak to strong on HeLa cell cultures [1].
The presence/absence of the cdtB gene as determined by PCR was confirmed by Southern hybridization and toxin production by HeLa cell-line experiments [1].

References

Cytolethal distending toxin B gene (cdtB) homologues in taxa 2, 3 and 8 and in six canine isolates of Helicobacter sp. flexispira. Kostia, S., Veijalainen, P., Hirvi, U., Hänninen, M.L. J. Med. Microbiol. (2003) [Pubmed]
Cytolethal distending toxin is essential for Helicobacter hepaticus colonization in outbred Swiss Webster mice. Ge, Z., Feng, Y., Whary, M.T., Nambiar, P.R., Xu, S., Ng, V., Taylor, N.S., Fox, J.G. Infect. Immun. (2005) [Pubmed]

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