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Gene Review:

TBSVgp4 - p22 protein

Tomato bushy stunt virus

Scholthof, H.B. et al., Scholthof, K.B. et al., Chu, M. et al., Scholthof, H.B. et al., Lin, H.X. et al.

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Disease relevance of TBSVgp4

In this study, we analyzed the influence of two nested genes (p19 and p22) of tomato bushy stunt virus (TBSV) on disease symptoms in systemically infected plants and in local lesion hosts [1].
The contribution of individual genes was determined by bioassays with an infectious clone of wild-type TBSV, with p19/p22 mutant derivatives, and by expression of individual TBSV genes from a heterologous potato virus X (PVX) vector [1].

High impact information on TBSVgp4

Transcription of sg mRNA2 in tombusviruses allows for expression of the p19 suppressor of gene silencing and p22 movement proteins [2].
The plus-sense single-stranded RNA of tomato bushy stunt virus (TBSV) encodes a 19-kDa protein, which is translated from a 3' proximal open reading frame (p19) that is entirely nested within the cell-to-cell movement gene (p22) [3].

Biological context of TBSVgp4

We have investigated the importance of two small nested genes (p19 and p22) located near the 3' end of the genome of tomato bushy stunt virus (TBSV) for infectivity in several hosts [4].

Other interactions of TBSVgp4

Associated with this differentially regulated suppression was a greatly reduced expression of both the p19 protein, which is responsible for severe symptoms, and the p22 protein, which is associated with cell-to-cell movement of the virus [5].

References

Identification of tomato bushy stunt virus host-specific symptom determinants by expression of individual genes from a potato virus X vector. Scholthof, H.B., Scholthof, K.B., Jackson, A.O. Plant Cell (1995) [Pubmed]
A complex network of RNA-RNA interactions controls subgenomic mRNA transcription in a tombusvirus. Lin, H.X., White, K.A. EMBO J. (2004) [Pubmed]
Genetic dissection of tomato bushy stunt virus p19-protein-mediated host-dependent symptom induction and systemic invasion. Chu, M., Desvoyes, B., Turina, M., Noad, R., Scholthof, H.B. Virology (2000) [Pubmed]
Tomato bushy stunt virus spread is regulated by two nested genes that function in cell-to-cell movement and host-dependent systemic invasion. Scholthof, H.B., Scholthof, K.B., Kikkert, M., Jackson, A.O. Virology (1995) [Pubmed]
The effect of defective interfering RNAs on the accumulation of tomato bushy stunt virus proteins and implications for disease attenuation. Scholthof, K.B., Scholthof, H.B., Jackson, A.O. Virology (1995) [Pubmed]

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