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Gene Review

VP  -  virion protein

Erysimum latent virus

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Disease relevance of VP

  • The ELV VP is larger than the VPs of other tymoviruses because it has, unexpectedly, 11 more amino acid residues at its N terminus [1].
  • Epitope analysis of antisera prepared against the virions of parental TYMV and some of the recombinants showed that, although the N terminus of the VP is immunogenically dominant, it is not exposed at the surface of the virion, a finding confirmed by comparing the electrophoretic mobilities of the virions [2].
  • A TYMV recombinant with the N-terminal part of its VP replaced with the E71 epitope of Plasmodium falciparum was also viable, but others with the same region replaced with the V3 region of the lentivirus human immunodeficiency virus type 1 were not [2].

High impact information on VP


Chemical compound and disease context of VP

  • The virion protein genes, and 3' untranslated regions, of six variants of turnip yellow mosaic tymovirus (TYMV) that produced different symptoms in their native host Cardamine robusta and in Chinese cabbage plants, have been sequenced [8].

Biological context of VP


Analytical, diagnostic and therapeutic context of VP

  • The recently published structure of the TYMV VP determined by X-ray crystallography confirms the accuracy of the predicted secondary structure of the VP, and hence the utility of the methods used [2].


  1. The primary structure of the virion protein gene and encoded protein of erysimum latent tymovirus. Srifah, P., Keese, P., Shukla, D., Gibbs, A. J. Gen. Virol. (1990) [Pubmed]
  2. Turnip yellow mosaic virus isolates with experimentally produced recombinant virion proteins. Hayden, C.M., Mackenzie, A.M., Skotnicki, M.L., Gibbs, A. J. Gen. Virol. (1998) [Pubmed]
  3. The tymobox, a sequence shared by most tymoviruses: its use in molecular studies of tymoviruses. Ding, S.W., Howe, J., Keese, P., Mackenzie, A., Meek, D., Osorio-Keese, M., Skotnicki, M., Srifah, P., Torronen, M., Gibbs, A. Nucleic Acids Res. (1990) [Pubmed]
  4. Nucleotide sequence of the virion protein gene of belladonna mottle tymovirus. Ding, S.W., Howe, J., Mackenzie, A., Skotnicki, M., Gibbs, A. Nucleic Acids Res. (1990) [Pubmed]
  5. Characterization of chimeric turnip yellow mosaic virus genomes that are infectious in the absence of aminoacylation. Goodwin, J.B., Skuzeski, J.M., Dreher, T.W. Virology (1997) [Pubmed]
  6. Nucleotide sequence of the genome of eggplant mosaic tymovirus. Osorio-Keese, M.E., Keese, P., Gibbs, A. Virology (1989) [Pubmed]
  7. Nature and specificity of the RNA-protein interaction in the case of the tymoviruses. Jonard, G., Briand, J.P., Bouley, J.P., Witz, J., Hirth, L. Philos. Trans. R. Soc. Lond., B, Biol. Sci. (1976) [Pubmed]
  8. Virion protein sequence variation among Australian isolates of turnip yellow mosaic tymovirus. Hayden, C.M., Mackenzie, A.M., Gibbs, A.J. Arch. Virol. (1998) [Pubmed]
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