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Gene Review

ABCC13  -  ATP-binding cassette, sub-family C...

Homo sapiens

Synonyms: C21orf73, PRED6
 
 
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High impact information on ABCC13

  • Here we show that while comparative analysis and in silico prediction methods indicate the presence of at least 28 exons, the major ABCC13 transcript in humans consists of only 6 exons with a total length of 1.1 kb [1].
  • The expression of ABCC13 in K562 cells decreased during cell differentiation induced by TPA [2].
  • The open reading frame of the ABCC13 cDNA encodes a peptide consisting of 325 amino acid residues [2].
  • These results suggest that the expression of human ABCC13 is related with hematopoiesis [2].
  • While ABCC13 was expressed in the bone marrow, its expression in peripheral blood leukocytes of adult humans was much lower and no detectable levels were observed in differentiated hematopoietic cells [2].
 

Biological context of ABCC13

References

  1. Degeneration of an ATP-binding cassette transporter gene, ABCC13, in different mammalian lineages. Annilo, T., Dean, M. Genomics (2004) [Pubmed]
  2. ABCC13, an unusual truncated ABC transporter, is highly expressed in fetal human liver. Yabuuchi, H., Takayanagi, S., Yoshinaga, K., Taniguchi, N., Aburatani, H., Ishikawa, T. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
 
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