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Gene Review

H2-T3  -  histocompatibility 2, T region locus 3

Mus musculus

Synonyms: H-2 class I histocompatibility antigen, TLA(B) alpha chain, H-2T3, H2-Tw3, MHC thymus leukemia antigen, TL
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Disease relevance of H2-T3

  • The results obtained thus far indicate that a majority of leukemias express TL antigen and differentiated Lyt phenotype [1].
  • As noted above, no attempts to elucidate the structure of the ligands bound to the TL antigen have so far succeeded, including the screening of bacteriophage display libraries (Castaño, A.R., Miller, J.E., Holcombe, H.R., unpublished data) [2].
  • TL antigen is not linked to radioinduced thymic lymphoma [3].

High impact information on H2-T3

  • Taken together, these results suggest that Tla2-3-TL antigen expressed in the thymus engages in positive selection of a sizable population of gamma delta T cells [4].
  • To elucidate the funciton of the mouse TL antigen in the thymus, we have derived two TL transgenic mouse strains by introducing Tl alpha 2-3 of A strain origin with its own promoter onto a C3H background with no expression of TL in the thymus [4].
  • These transgenic mouse strains, both of which express high levels of Tla2-3-TL antigen in their thymus, were analyzed for their T cell function with emphasis on cytotoxic T lymphocyte (CTL) generation [4].
  • Here we present data demonstrating that expression of the TL antigen, unlike other class I molecules, is completely independent of the function of the transporter associated with antigen processing (TAP) [5].
  • The TL antigen is expressed by transfected TAP-2-deficient RMA-S cells when these cells are grown at 37 degrees C. In transfected RMA cells, the kinetics of arrival of TL antigen on the cell surface are similar to those of a classical class I molecule [5].

Biological context of H2-T3

  • Analysis of the DNA sequence shows, however, that this gene, the T1c gene from the Tlac genotype, could not encode a TL antigen or any other functional class I molecule due to the presence of numerous stop codons and frameshift mutations in the coding regions [6].
  • The restricted expression of Ly antigens on differentiating thymus cells to either the (formula: see text), phenotype may occur before the loss of TL antigen [7].
  • Both Tg.Tlaa-3 strains expressed high levels of TL antigen in thymus, indicating that (i) the 9.6-kilobase Tlaa-3 DNA fragment contains sufficient information for correct tissue-specific expression in thymocytes and (ii) TL- thymocytes of C3H provide conditions for the transcriptional activation of Tlaa-3 [8].
  • Regulation of TL antigen expression. Analysis of the T18d promoter region and responses to IFN-gamma [9].
  • The assay has also been used to quantitate the changes in TL antigen expression on cells incubated in anti-TL antisera under conditions of antigenic modulation [10].

Anatomical context of H2-T3

  • Positive selection of gamma delta CTL by TL antigen expressed in the thymus [4].
  • TL antigen in mouse appears to be analogous to T-6 antigen previously detected on human Langerhans cells [11].
  • We speculate that the ability of the TL antigen to reach the cell surface, under conditions in which other class I molecules do not, may be related to a specialized function of the TL molecule in the mucosal immune system, and possibly in the stimulation of intestinal gamma delta T cells [5].
  • Our results show that the TL antigen gene of C57BL/6 mice, T3b, and the TL antigen genes of BALB/c mice, T3d (previously T3c) and T18d (previously T13c), are highly expressed in the epithelium of the small intestine [12].
  • The cell lines, except ERLD/T, possess the TL antigen, a characteristic of ERLD and of other murine leukemia cells in vivo and of normal thymus cells of certain mouse strains, but not of C57BL/6 [13].

Other interactions of H2-T3


Analytical, diagnostic and therapeutic context of H2-T3


  1. Expression of Thy1, TL and LYT antigens on spontaneous leukemias of BALB/MO strain of mice. Strzadała, L., Opolski, A., Kisielow, P. Arch. Immunol. Ther. Exp. (Warsz.) (1981) [Pubmed]
  2. Antigen-presenting function of the TL antigen and mouse CD1 molecules. Cheroutre, H., Holcombe, H.R., Tangri, S., Castaño, A.R., Teitell, M., Miller, J.E., Cardell, S., Benoist, C., Mathis, D., Huse, W.D. Immunol. Rev. (1995) [Pubmed]
  3. TL antigen is not linked to radioinduced thymic lymphoma. Boudreau, R., St-Pierre, Y., Beauchemin, C., Potworowski, E.F. Cell. Immunol. (1998) [Pubmed]
  4. Positive selection of gamma delta CTL by TL antigen expressed in the thymus. Tsujimura, K., Takahashi, T., Morita, A., Hasegawa-Nishiwaki, H., Iwase, S., Obata, Y. J. Exp. Med. (1996) [Pubmed]
  5. Nonclassical behavior of the thymus leukemia antigen: peptide transporter-independent expression of a nonclassical class I molecule. Holcombe, H.R., Castaño, A.R., Cheroutre, H., Teitell, M., Maher, J.K., Peterson, P.A., Kronenberg, M. J. Exp. Med. (1995) [Pubmed]
  6. DNA sequence of a class I pseudogene from the Tla region of the murine MHC: recombination at a B2 alu repetitive sequence. Fisher, D.A., Pecht, M., Hood, L. J. Mol. Evol. (1989) [Pubmed]
  7. Expression of Ly 1, Ly 2, Thy 1, and TL differentiation antigens on mouse T-cell tumors. Mathieson, B.J., Campbell, P.S., Potter, M., Asofsky, R. J. Exp. Med. (1978) [Pubmed]
  8. Expression of TL, H-2, and chimeric H-2/TL genes in transgenic mice: abnormal thymic differentiation and T-cell lymphomas in a TL transgenic strain. Hamasima, N., Takahashi, T., Taguchi, O., Nishizuka, Y., Stockert, E., Old, L.J., Obata, Y. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  9. Regulation of TL antigen expression. Analysis of the T18d promoter region and responses to IFN-gamma. Wang, I.M., Mehta, V., Cook, R.G. J. Immunol. (1993) [Pubmed]
  10. An indirect radioimmunoassay for thymus leukemia (TL) antigens. Esmon, N.L., Little, J.R. J. Immunol. (1976) [Pubmed]
  11. Antigens specified by the Tla locus are expressed on the surface of murine Langerhans cells. Rowden, G., Misra, B., Higley, H., Howard, R. J. Invest. Dermatol. (1983) [Pubmed]
  12. Highly restricted expression of the thymus leukemia antigens on intestinal epithelial cells. Wu, M., van Kaer, L., Itohara, S., Tonegawa, S. J. Exp. Med. (1991) [Pubmed]
  13. Radiation-induced murine leukemia ERLD in cell culture. Albrecht, A.M., Biedler, J.L., Hutchison, D.J., Spengler, B.A., Stockert, E. Cancer Res. (1976) [Pubmed]
  14. Further polymorphism of the Tla locus defined by monoclonal TL antibodies. Shen, F.W., Chorney, M.J., Boyse, E.A. Immunogenetics (1982) [Pubmed]
  15. Abnormal thymic development, impaired immune function and gamma delta T cell lymphomas in a TL transgenic mouse strain. Obata, Y., Taguchi, O., Matsudaira, Y., Hasegawa, H., Hamasima, N., Takahashi, T. J. Exp. Med. (1991) [Pubmed]
  16. Characteristics of thymus-homing bone marrow cells. Lepault, F., Coffman, R.L., Weissman, I.L. J. Immunol. (1983) [Pubmed]
  17. Structural evidence that the small subunit found associated with the TL antigen is beta 2-microglobulin. Yokoyama, K., Stockert, E., Old, L.J., Nathenson, S.G. Immunogenetics (1982) [Pubmed]
  18. TL antigen as a transplantation antigen recognized by TL-restricted cytotoxic T cells. Morita, A., Takahashi, T., Stockert, E., Nakayama, E., Tsuji, T., Matsudaira, Y., Old, L.J., Obata, Y. J. Exp. Med. (1994) [Pubmed]
  19. Structural identity of the TL antigen homologues derived from strain 2 and strain 13 guinea pigs. Surratt, R.S., Abruzzini, L.N., Zacheis, M.P., Cigen, R., Schwartz, B.D. J. Immunol. (1983) [Pubmed]
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