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Hnrnpk  -  heterogeneous nuclear ribonucleoprotein K

Mus musculus

Synonyms: Heterogeneous nuclear ribonucleoprotein K, Hnrpk, KBBP, NOVA, hnRNP K, ...
 
 
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Disease relevance of Hnrpk

  • All tested Nocardia brasiliensis strains as well as the producer itself were resistant to SO-75R1, although four other pathogenic Nocardia, i.e. N. asteroides, N. nova, N. farcinica and N. otitidiscaviarum were sensitive [corrected] [1].
 

High impact information on Hnrpk

 

Biological context of Hnrpk

  • Epidermal barrier was evaluated as the change in surface hydration by surface electrical capacitance with the NOVA Dermal Phase Meter [6].
  • LD50 values for N. nova and N. asteroides were not significantly different [7].
  • This map revealed that the position of Nova binding sites (YCAY clusters) in a pre-messenger RNA determines the outcome of splicing [8].
  • These results define a genome-wide map relating the position of a cis-acting element to its regulation by an RNA binding protein, namely that Nova binding to YCAY clusters results in a local and asymmetric action to regulate spliceosome assembly and alternative splicing in neurons [8].
  • We have combined bioinformatics, biochemistry and genetics to derive an RNA map describing the rules by which Nova proteins regulate alternative splicing [8].
 

Associations of Hnrpk with chemical compounds

  • In contrast, cycloheximide stimulated the induction; this suggests that de nova protein synthesis is important in the regulation of the ESP-induced expression of iNOS mRNA [9].
  • Effects of dieldrin on de nova RNA purine synthesis from formate in vivo were slight, while mirex inhibited the synthesis of both RNA purines [10].
  • De nova biosynthesis of pyrimidine and purine was also affected [11].
 

Other interactions of Hnrpk

  • Sam68 stimulates G1/S transition and this effect is dependent on the integrity of its KH domain (hnRNPK Homology) which confers nucleic acid binding properties [12].

References

  1. The producer and biological activities of SO-75R1, a new mutactimycin group antibiotic [corrected]. Maeda, A., Yazawa, K., Mikami, Y., Ishibashi, M., Kobayashi, J. J. Antibiot. (1992) [Pubmed]
  2. Function of quaking in myelination: regulation of alternative splicing. Wu, J.I., Reed, R.B., Grabowski, P.J., Artzt, K. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. Interaction of N-WASP with hnRNPK and its role in filopodia formation and cell spreading. Yoo, Y., Wu, X., Egile, C., Li, R., Guan, J.L. J. Biol. Chem. (2006) [Pubmed]
  4. Purification, cloning, and expression of a murine phosphoprotein that binds the kappa B motif in vitro identifies it as the homolog of the human heterogeneous nuclear ribonucleoprotein K protein. Description of a novel DNA-dependent phosphorylation process. Ostrowski, J., Van Seuningen, I., Seger, R., Rauch, C.T., Sleath, P.R., McMullen, B.A., Bomsztyk, K. J. Biol. Chem. (1994) [Pubmed]
  5. Expression of a novel isoform of Vav, Vav-T, containing a single Src homology 3 domain in murine testicular germ cells. Okumura, K., Kaneko, Y., Nonoguchi, K., Nishiyama, H., Yokoi, H., Higuchi, T., Itoh, K., Yoshida, O., Miki, T., Fujita, J. Oncogene (1997) [Pubmed]
  6. Incubation of cultured skin substitutes in reduced humidity promotes cornification in vitro and stable engraftment in athymic mice. Supp, A.P., Wickett, R.R., Swope, V.B., Harriger, M.D., Hoath, S.B., Boyce, S.T. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. (1999) [Pubmed]
  7. Mouse pathogenicity studies of Nocardia asteroides complex species and clinical correlation with human isolates. Desmond, E.P., Flores, M. FEMS Microbiol. Lett. (1993) [Pubmed]
  8. An RNA map predicting Nova-dependent splicing regulation. Ule, J., Stefani, G., Mele, A., Ruggiu, M., Wang, X., Taneri, B., Gaasterland, T., Blencowe, B.J., Darnell, R.B. Nature (2006) [Pubmed]
  9. Excretory/secretory products of plerocercoids of Spirometra erinaceieuropaei induce the expression of inducible nitric oxide synthase mRNA in murine hepatocytes. Wang, H., Tanihata, T., Fukumoto, S., Hirai, K. Int. J. Parasitol. (1997) [Pubmed]
  10. Some effects of dieldrin and mirex on Ehrlich ascites tumor cells in vivo and in vitro. Walker, E.M., Gale, G.R., Atkins, L.M., Gadsden, R.H. Arch. Environ. Contam. Toxicol. (1977) [Pubmed]
  11. Synthesis and antitumor activity of 5-bromo-1-mesyluracil. Glava-Obrovac, L., Karner, I., Pavlak, M., Radacić, M., Kasnar-Samprec, J., Zinić, B. Nucleosides Nucleotides Nucleic Acids (2005) [Pubmed]
  12. Sam68 is a Ras-GAP-associated protein in mitosis. Guitard, E., Barlat, I., Maurier, F., Schweighoffer, F., Tocque, B. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
 
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