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Hnrnpl  -  heterogeneous nuclear ribonucleoprotein L

Mus musculus

Synonyms: C79783, D830027H13Rik, Heterogeneous nuclear ribonucleoprotein L, Hnrpl, hnRNP L
 
 
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High impact information on Hnrpl

  • Thus, decreased surface alpha2beta1 results from decreased Itga2 pre-mRNA splicing regulated by hnRNP L and depends on CA repeat length at a specific site in intron 1 [1].
  • hnRNP L regulates differences in expression of mouse integrin alpha2beta1 [1].
  • The splicing enhancer activity of CA21 in vivo is abolished by prior treatment with hnRNP L-specific siRNA [1].
  • Open reading frame analysis provided a putative amino acid sequence consistent with the identity of PRG1 as rat hnRNP-L [2].
  • Western blot analysis revealed significantly decreased hnRNP-L levels in the striatum and pre-frontal cortex (but not the nucleus accumbens) by 71 and 61%, respectively of PLG-treated animals [2].
 

Biological context of Hnrpl

  • Decreased alpha2beta1 in 4 strains carrying Itga2 haplotype 2 results from decreased affinity of heterogeneous ribonucleoprotein L (hnRNP L) for a 6 CA repeat sequence (CA6) within intron 1 [1].
  • Finally, mapping studies of the 3' UTR of VEGF mRNA show that deletion of the heterogeneous nuclear ribonucleoprotein l binding site affects basal reporter expression in RAW-264.7 cells, but does not affect reporter activation with LPS [3].
 

Analytical, diagnostic and therapeutic context of Hnrpl

References

  1. hnRNP L regulates differences in expression of mouse integrin alpha2beta1. Cheli, Y., Kunicki, T.J. Blood (2006) [Pubmed]
  2. PLG regulates hnRNP-L expression in the rat striatum and pre-frontal cortex: identification by ddPCR. Costain, W.J., Mishra, R.K. Peptides (2003) [Pubmed]
  3. VEGF gene expression is regulated post-transcriptionally in macrophages. Du, M., Roy, K.M., Zhong, L., Shen, Z., Meyers, H.E., Nichols, R.C. FEBS J. (2006) [Pubmed]
 
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