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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Hoxc4  -  homeobox C4

Mus musculus

Synonyms: Homeobox protein Hox-3.5, Homeobox protein Hox-C4, Hox-3.5, Hoxc-4
 
 
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High impact information on Hoxc4

  • Neurons induced by beta-catenin overexpression either alone or in association with RA express the caudal neuronal marker Hoxc4 [1].
  • Within the hindbrain, the Hox-3.5 boundary is seen to lie posterior to that of its paralogue, Hox-2.6, by a distance equal to about the length of one rhombomere [2].
  • The murine Hox-3.5 gene has been mapped and linked genomically to a position 18 kb 3' of its most 5' locus neighbour, Hox-3.4, on chromosome 15 [2].
  • Although Hoxc-4 is expressed abundantly in the central nervous system, no obvious defects were observed [3].
  • Hoxc-4 is a mouse homeobox gene located at the 3' end of the HoxC cluster [3].
 

Analytical, diagnostic and therapeutic context of Hoxc4

References

  1. Beta-catenin signaling is required for neural differentiation of embryonic stem cells. Otero, J.J., Fu, W., Kan, L., Cuadra, A.E., Kessler, J.A. Development (2004) [Pubmed]
  2. Sequence and embryonic expression of the murine Hox-3.5 gene. Geada, A.M., Gaunt, S.J., Azzawi, M., Shimeld, S.M., Pearce, J., Sharpe, P.T. Development (1992) [Pubmed]
  3. Targeted disruption in the mouse Hoxc-4 locus results in axial skeleton homeosis and malformation of the xiphoid process. Saegusa, H., Takahashi, N., Noguchi, S., Suemori, H. Dev. Biol. (1996) [Pubmed]
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