Gene Review:
Iapp - islet amyloid polypeptide
Mus musculus
Synonyms:
Amylin, DAP, Diabetes-associated peptide, Islet amyloid polypeptide, amylin
- Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo. Dacquin, R., Davey, R.A., Laplace, C., Levasseur, R., Morris, H.A., Goldring, S.R., Gebre-Medhin, S., Galson, D.L., Zajac, J.D., Karsenty, G. J. Cell Biol. (2004)
- Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide. Janson, J., Soeller, W.C., Roche, P.C., Nelson, R.T., Torchia, A.J., Kreutter, D.K., Butler, P.C. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Induction of insulin and islet amyloid polypeptide production in pancreatic islet glucagonoma cells by insulin promoter factor 1. Serup, P., Jensen, J., Andersen, F.G., Jørgensen, M.C., Blume, N., Holst, J.J., Madsen, O.D. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Islet amyloid polypeptide (amylin)-deficient mice develop a more severe form of alloxan-induced diabetes. Mulder, H., Gebre-Medhin, S., Betsholtz, C., Sundler, F., Ahrén, B. Am. J. Physiol. Endocrinol. Metab. (2000)
- Immunochemical investigation of insulinomas for islet amyloid polypeptide and insulin: evidence for differential synthesis and storage. Williams, A.J., Coates, P.J., Lowe, D.G., McLean, C., Gale, E.A. Histopathology (1992)
- Differential effects of amylin on memory processing using peripheral and central routes of administration. Flood, J.F., Morley, J.E. Peptides (1992)
- Amylin, released from the gastric fundus, stimulates somatostatin and thus inhibits histamine and acid secretion in mice. Zaki, M., Koduru, S., McCuen, R., Vuyyuru, L., Schubert, M.L. Gastroenterology (2002)
- The expression of Escherichia coli diaminopimelate decarboxylase in mouse 3T3 cells. Saqib, K.M., Hay, S.M., Rees, W.D. Biochim. Biophys. Acta (1994)
- Characterization of amylin and calcitonin receptor binding in the mouse alpha-thyroid-stimulating hormone thyrotroph cell line. Perry, K.J., Quiza, M., Myers, D.E., Morfis, M., Christopoulos, G., Sexton, P.M. Endocrinology (1997)
- Failure of islet amyloid polypeptide to inhibit basal and glucose-stimulated insulin secretion in model experiments in mice and rats. Pettersson, M., Ahrén, B. Acta Physiol. Scand. (1990)
- Reduced nociceptive behavior in islet amyloid polypeptide (amylin) knockout mice. Gebre-Medhin, S., Mulder, H., Zhang, Y., Sundler, F., Betsholtz, C. Brain Res. Mol. Brain Res. (1998)
- Islet amyloid polypeptide-like immunoreactivity in the islet B cells of type 2 (non-insulin-dependent) diabetic and non-diabetic individuals. Westermark, P., Wilander, E., Westermark, G.T., Johnson, K.H. Diabetologia (1987)
- Amylin and adrenomedullin: novel regulators of bone growth. Cornish, J., Naot, D. Curr. Pharm. Des. (2002)
- Modulation of food intake by peripherally administered amylin. Morley, J.E., Flood, J.F., Horowitz, M., Morley, P.M., Walter, M.J. Am. J. Physiol. (1994)
- Mutation at position -132 in the islet amyloid polypeptide ( IAPP) gene promoter enhances basal transcriptional activity through a new CRE-like binding site. Novials, A., Mato, E., Lucas, M., Franco, C., Rivas, M., Santisteban, P., Gomis, R. Diabetologia (2004)
- Transcription factor occupancy of the insulin gene in vivo. Evidence for direct regulation by Nkx2.2. Cissell, M.A., Zhao, L., Sussel, L., Henderson, E., Stein, R. J. Biol. Chem. (2003)
- Binding sites for islet amyloid polypeptide in mammalian lung: species variation and effects on adenylyl cyclase. Bhogal, R., Smith, D.M., Owji, A.A., Bloom, S.R. Can. J. Physiol. Pharmacol. (1995)
- Amylin and food intake in mice: effects on motivation to eat and mechanism of action. Morley, J.E., Suarez, M.D., Mattamal, M., Flood, J.F. Pharmacol. Biochem. Behav. (1997)
- Inhibition of food intake. Young, A. Adv. Pharmacol. (2005)
- Islet amyloid polypeptide inhibits glucagon release and exerts a dual action on insulin release from isolated islets. Akesson, B., Panagiotidis, G., Westermark, P., Lundquist, I. Regul. Pept. (2003)
- Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide. Marzban, L., Trigo-Gonzalez, G., Zhu, X., Rhodes, C.J., Halban, P.A., Steiner, D.F., Verchere, C.B. Diabetes (2004)
- Reduced ghrelin, islet amyloid polypeptide, and peptide YY expression in the stomach of gastrin-cholecystokinin knockout mice. Friis-Hansen, L., Wierup, N., Rehfeld, J.F., Sundler, F. Endocrinology (2005)
- Role of carboxypeptidase E in processing of pro-islet amyloid polypeptide in {beta}-cells. Marzban, L., Soukhatcheva, G., Verchere, C.B. Endocrinology (2005)
- Salmon calcitonin - a potent inhibitor of food intake in states of impaired leptin signalling in laboratory rodents. Eiden, S., Daniel, C., Steinbrueck, A., Schmidt, I., Simon, E. J. Physiol. (Lond.) (2002)