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Gene Review

RHOXF1  -  Rhox homeobox family, member 1

Homo sapiens

Synonyms: OTEX, Ovary-, testis-and epididymis-expressed gene protein, PEPP1, Paired-like homeobox protein PEPP-1, Rhox homeobox family member 1
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High impact information on OTEX

  • A phylogenetic analysis revealed that OTEX belonged to the recently defined PEPP subfamily of paired-like homeobox genes [1].
  • In the PC-3/ARwt prostate cell line, OTEX expression was stimulated dramatically following androgen treatment [1].
  • No inherent transactivation function was seen for OTEX using the one-hybrid assay, and no homodimer formation was observed in the two-hybrid assay, suggesting that additional partners were needed for this activity [1].
  • Mutation of the RARCRRHQRE amino acid sequence present at the C-terminus of the OTEX homeodomain resulted in a mainly cytoplasmic localization, indicating that this motif harboured the nuclear localization signal [1].
  • It was organized into three introns and, like the other PEPP genes, it was mapped to chromosome X. Its transcripts were detected mainly in the ovary, testis and epididymis, but also in the prostate and mammary gland [1].

Biological context of OTEX

  • The PEPP genes are a recently described subfamily of mouse homeobox genes preferentially expressed in reproductive tissues [2].

Anatomical context of OTEX

  • We conclude that we identified two human homeobox genes from the PEPP subfamily that are good candidates to encode transcription factors that regulate downstream genes and biological events in the human testis [2].

Other interactions of OTEX

  • Taken together, the data show that OTEX represents a novel, androgen-regulated, paired-like homeobox protein, with possibly an important role in human reproduction [1].
  • Two novel human X-linked homeobox genes, hPEPP1 and hPEPP2, selectively expressed in the testis [2].

Analytical, diagnostic and therapeutic context of OTEX


  1. OTEX, an androgen-regulated human member of the paired-like class of homeobox genes. Geserick, C., Weiss, B., Schleuning, W.D., Haendler, B. Biochem. J. (2002) [Pubmed]
  2. Two novel human X-linked homeobox genes, hPEPP1 and hPEPP2, selectively expressed in the testis. Wayne, C.M., MacLean, J.A., Cornwall, G., Wilkinson, M.F. Gene (2002) [Pubmed]
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