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Gene Review: 

Ide  -  insulin degrading enzyme

Mus musculus

Synonyms: 1300012G03Rik, 4833415K22Rik, AA675336, AI507533, Insulin protease, ...
 
 
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Psychiatry related information on Ide

  • These findings indicate that there is an inverse correlation between in vivo insulysin activity levels and brain Abeta peptide levels and suggest that modulation of insulysin activity may alter the risk for Alzheimer's disease [1].
 

High impact information on Ide

  • A 6-fold increase in the level of the gamma-secretase-generated C-terminal fragment of the Abeta precursor protein in the insulysin-deficient mouse also was found [1].
  • Purkinje cells are "translocated" ventrally correlated with a similar translocation of vestibular single units described previuosly (Ide, '77) [2].
  • The murine Ide gene was previously mapped to Chromosome 19; together, these results suggest that the IDE gene is a member of a conserved syntenic group on human chromosome 10, bands q23----q25 and mouse Chromosome 19 [3].
 

Biological context of Ide

References

  1. Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo. Miller, B.C., Eckman, E.A., Sambamurti, K., Dobbs, N., Chow, K.M., Eckman, C.B., Hersh, L.B., Thiele, D.L. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. Neuroanatomy of Spastic, a behavior mutant of the mexican axoloti: Purkinje cell distribution in the adult cerebellum. Ide, C.F., Tompkins, R., Miszkowski, N. J. Comp. Neurol. (1977) [Pubmed]
  3. Localization of the gene encoding insulin-degrading enzyme to human chromosome 10, bands q23----q25. Espinosa, R., Lemons, R.S., Perlman, R.K., Kuo, W.L., Rosner, M.R., Le Beau, M.M. Cytogenet. Cell Genet. (1991) [Pubmed]
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