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Gene Review:

Lef1 - lymphoid enhancer binding factor 1

Rattus norvegicus

Synonyms: LEF-1, Lymphoid enhancer-binding factor 1

Bettini, E. et al., Kaga, S. et al., Chou, A.H. et al.

Bettini, Magnani, Terstappen,

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High impact information on Lef1

We suggest that bisindolylmaleimide-I acts by affecting either a pathway downstream from Lef-1/Tcf in the canonical pathway or a Wnt signaling pathway other than the canonical pathway [1].
The present study attempts to address whether GSK-3beta-beta-catenin signaling in turn interacts with T-cell transcription factor/lymphoid-enhancer binding factor (TCF/LEF) and regulates these genes in the ischemic preconditioned myocardium [2].
In some cell types, but not in others, activated beta-catenin interacts with members of the lymphoid enhancer-binding factor (LEF)/T-cell factor (TCF) family of transcription factors and induces gene expression [3].
Lithium effect on LEF/TCF-mediated gene expression has never been evaluated in cells with a neuronal phenotype [3].
Lithium induces gene expression through lymphoid enhancer-binding factor/T-cell factor responsive element in rat PC12 cells [3].

Biological context of Lef1

We have constructed a LEF/TCF-dependent luciferase reporter gene to investigate lithium effects on transcription in PC12 cells [3].

Anatomical context of Lef1

In transiently transfected PC12 cells, lithium induced a time-dependent increase in LEF/TCF-mediated luciferase activity [3].

References

Inhibition by Wnt-1 or Wnt-3a of nerve growth factor-induced differentiation of PC12 cells is reversed by bisindolylmaleimide-I but not by several other PKC inhibitors. Chou, A.H., Howard, B.D. Oncogene (2002) [Pubmed]
Glycogen synthase kinase-3beta/beta-catenin promotes angiogenic and anti-apoptotic signaling through the induction of VEGF, Bcl-2 and survivin expression in rat ischemic preconditioned myocardium. Kaga, S., Zhan, L., Altaf, E., Maulik, N. J. Mol. Cell. Cardiol. (2006) [Pubmed]
Lithium induces gene expression through lymphoid enhancer-binding factor/T-cell factor responsive element in rat PC12 cells. Bettini, E., Magnani, E., Terstappen, G.C. Neurosci. Lett. (2002) [Pubmed]

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