Gene Review:
Jrk - jerky
Mus musculus
Synonyms:
Jerky protein
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High impact information on Jrk
- These data suggest that epileptogenesis in Jerky-deficient mice most likely involves pathways associated with ribosome biogenesis and neuronal survival and/or apoptosis [1].
- A deficit in the Jerky protein in mice causes recurrent seizures reminiscent of temporal lobe epilepsy [1].
- The binding domain is similar to the two tandemly arranged homeodomain-like helix-turn-helix DNA binding motifs of centromere binding protein B. The putative helix-turn-helix motifs of Jerky can also bind double-stranded DNA and represent a novel mammalian RNA/DNA binding domain [1].
Analytical, diagnostic and therapeutic context of Jrk
- Microarray analysis identified mRNAs encoding proteins involved in ribosome assembly and cellular stress response that specifically bound to the RNA binding domain of Jerky both in vitro and in vivo [1].
References
- The RNA binding domain of Jerky consists of tandemly arranged helix-turn-helix/homeodomain-like motifs and binds specific sets of mRNAs. Liu, W., Seto, J., Sibille, E., Toth, M. Mol. Cell. Biol. (2003) [Pubmed]
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