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Gene Review

Kcnj8  -  potassium inwardly-rectifying channel,...

Mus musculus

Synonyms: AI448900, ATP-sensitive inward rectifier potassium channel 8, Inward rectifier K(+) channel Kir6.1, Kir6.1, Potassium channel, inwardly rectifying subfamily J member 8, ...
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High impact information on Kcnj8

  • Our studies of ATP-sensitive K+ channel (K(ATP)) trafficking reveal an essential quality control function for a trafficking motif present in each of the alpha (Kir6.1/2) and beta (SUR1) subunits of the K(ATP) complex [1].
  • 2. We next probed the ability of Kir6.1 and Kir6.2 to affect endogenous K(ATP) channels in adult rabbit ventricular myocytes, using adenoviral vectors to achieve efficient gene transfer [2].
  • Cystic fibrosis transmembrane conductance regulator mediates sulphonylurea block of the inwardly rectifying K+ channel Kir6.1 [3].
  • Regardless of co-transfection with Kir6.1, the transfection with CFTR produced a Cl- conductance that was activated by cell dialysis with cAMP (1 mM) [3].
  • 3. Whole-cell currents at +60 mV were blocked in a concentration-dependent manner by Ba2+ ions with similar IC50 values: 89.3 +/- 23.3 microM (Kir6.1 alone) and 67.3 +/- 24.9 microM (Kir6.1-CFTR) [3].

Biological context of Kcnj8


Anatomical context of Kcnj8


Associations of Kcnj8 with chemical compounds

  • Investigation of the channel composition was performed with antibodies against K(ATP)-channel subunits, namely the sulfonylurea receptor (SUR1 or SUR2) and the inwardly rectifying K+ channel (Kir6.1 or Kir6.2) [8].
  • In the SAN from ivabradine-treated mice, the expression of nine ion channel subunits, including Navbeta1 (-25%), Cav3.1 (-29%), Kir6.1 (-28%), Kvbeta2 (-41%), and Kvbeta3 (-30%), was significantly decreased [9].

Other interactions of Kcnj8


Analytical, diagnostic and therapeutic context of Kcnj8


  1. A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane K(ATP) channels. Zerangue, N., Schwappach, B., Jan, Y.N., Jan, L.Y. Neuron (1999) [Pubmed]
  2. Evidence against functional heteromultimerization of the KATP channel subunits Kir6.1 and Kir6.2. Seharaseyon, J., Sasaki, N., Ohler, A., Sato, T., Fraser, H., Johns, D.C., O'Rourke, B., Marbán, E. J. Biol. Chem. (2000) [Pubmed]
  3. Cystic fibrosis transmembrane conductance regulator mediates sulphonylurea block of the inwardly rectifying K+ channel Kir6.1. Ishida-Takahashi, A., Otani, H., Takahashi, C., Washizuka, T., Tsuji, K., Noda, M., Horie, M., Sasayama, S. J. Physiol. (Lond.) (1998) [Pubmed]
  4. Sur2 and Kcnj8 genes are tightly linked on the distal region of mouse chromosome 6. Isomoto, S., Horio, Y., Matsumoto, S., Kondo, C., Yamada, M., Gilbert, D.J., Copeland, N.G., Jenkins, N.A., Kurachi, Y. Mamm. Genome (1997) [Pubmed]
  5. Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channel. Yamada, M., Isomoto, S., Matsumoto, S., Kondo, C., Shindo, T., Horio, Y., Kurachi, Y. J. Physiol. (Lond.) (1997) [Pubmed]
  6. Microarray analysis of blood microvessels from PDGF-B and PDGF-Rbeta mutant mice identifies novel markers for brain pericytes. Bondjers, C., He, L., Takemoto, M., Norlin, J., Asker, N., Hellström, M., Lindahl, P., Betsholtz, C. FASEB J. (2006) [Pubmed]
  7. Immunolocalization of KATP channel subunits in mouse and rat cardiac myocytes and the coronary vasculature. Morrissey, A., Rosner, E., Lanning, J., Parachuru, L., Dhar Chowdhury, P., Han, S., Lopez, G., Tong, X., Yoshida, H., Nakamura, T.Y., Artman, M., Giblin, J.P., Tinker, A., Coetzee, W.A. BMC Physiol. (2005) [Pubmed]
  8. Heart mitochondria contain functional ATP-dependent K+ channels. Lacza, Z., Snipes, J.A., Miller, A.W., Szabó, C., Grover, G., Busija, D.W. J. Mol. Cell. Cardiol. (2003) [Pubmed]
  9. Chronic heart rate reduction remodels ion channel transcripts in the mouse sinoatrial node but not in the ventricle. Leoni, A.L., Marionneau, C., Demolombe, S., Le Bouter, S., Mangoni, M.E., Escande, D., Charpentier, F. Physiol. Genomics (2005) [Pubmed]
  10. Mutational analysis of Kir6.1 in Japanese patients with coronary spastic angina. Tomita, H., Sasaki, S., Osanai, T., Nakano, T., Higuma, T., Yokoyama, J., Hanada, H., Yasujima, M., Okumura, K. Int. J. Mol. Med. (2006) [Pubmed]
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