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Gene Review

Hivep3  -  human immunodeficiency virus type I...

Mus musculus

Synonyms: 2900056N03Rik, A130075N07, AI848000, E030045D18Rik, Human immunodeficiency virus type I enhancer-binding protein 3 homolog, ...
 
 
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Disease relevance of Hivep3

  • 5B10 did not bind to LPS from E. coli J5, an Rc mutant of E. coli 0111:B4 that lacks both the O-antigen and outer core sugars [1].
  • Antiserum to the epimeraseless Rc mutant of Salmonella minnesota was prepared by immunization of rabbits [2].
  • Passive protection against heterologous gram-negative bacteria mediated by antiserum to epimeraseless Rc mutant of Salmonella minnesota [2].
 

High impact information on Hivep3

  • The V(D)J recombination signal sequence and kappa B binding protein Rc binds DNA as dimers and forms multimeric structures with its DNA ligands [3].
  • Here, we first quantified short Ob-R mRNA expression in isolated rat cerebral microvessels constituting the blood-brain barrier and found that Ob-Ra and Ob-Rc mRNA were abundantly expressed in similar amounts [4].
  • Cloning and characterization of a mouse Rc gene show that the Rc cDNA corresponds to seven exons located in a genomic region spanning 70 kb [5].
  • Rc is a DNA binding protein with dual specificities for the V(D)J recombination signal sequences and for the B motif of the immunoglobulin kappa chain gene enhancer [5].
  • The largest Rc transcript present in lymphoid cells/tissues is approximately 9 kb [5].
 

Biological context of Hivep3

  • The mouse DNA binding protein Rc for the kappa B motif of transcription and for the V(D)J recombination signal sequences contains composite DNA-protein interaction domains and belongs to a new family of large transcriptional proteins [5].
  • The middle region of Rc contains a lone zinc finger, an acidic motif, a Ser-rich region, a nucleus localization signal, and GTPase motifs [5].
  • Molecular cloning and sequence determination for 8822 bp of mouse Rc cDNA revealed an open reading frame of 2282 amino acids and long 5'- and 3'-untranslated regions [5].
  • Exon 2 is exceptionally large, with 5487 bp. cDNA cloning and Northern blot analyses revealed multiple Rc transcripts, probably generated by alternative splicings [5].
  • Male 8-month-old SAMP10 and its homologous SAMRl were selected and randomly divided into four groups: R1 control group (Rc), P10 control group (Pc), P10 acupuncture group (Pa) and P10 non-acupoint group (Pn) [6].
 

Analytical, diagnostic and therapeutic context of Hivep3

  • Bacterial fusion proteins for Rc and DNA ligands of Rc form multiple protein-DNA complexes in electrophoretic mobility shift assays (EMSA) [3].

References

  1. Immunoprotective murine monoclonal antibodies specific for the outer-core polysaccharide and for the O-antigen of Escherichia coli 0111:B4 lipopolysaccharide (LPS). Coughlin, R.T., Bogard, W.C. J. Immunol. (1987) [Pubmed]
  2. Passive protection against heterologous gram-negative bacteria mediated by antiserum to epimeraseless Rc mutant of Salmonella minnesota. Konstantinov, G., Karacholeva, M., Eskenazy, M., Ivanova, R., Vassileva, J., Naumova, F., Tekelieva, R., Strahilov, D. Ann. Immunol. (Paris) (1982) [Pubmed]
  3. The V(D)J recombination signal sequence and kappa B binding protein Rc binds DNA as dimers and forms multimeric structures with its DNA ligands. Mak, C.H., Strandtmann, J., Wu, L.C. Nucleic Acids Res. (1994) [Pubmed]
  4. Characterizaton of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity. Hileman, S.M., Pierroz, D.D., Masuzaki, H., Bjørbaek, C., El-Haschimi, K., Banks, W.A., Flier, J.S. Endocrinology (2002) [Pubmed]
  5. The mouse DNA binding protein Rc for the kappa B motif of transcription and for the V(D)J recombination signal sequences contains composite DNA-protein interaction domains and belongs to a new family of large transcriptional proteins. Wu, L.C., Liu, Y., Strandtmann, J., Mak, C.H., Lee, B., Li, Z., Yu, C.Y. Genomics (1996) [Pubmed]
  6. Acupuncture regulates the aging-related changes in gene profile expression of the hippocampus in senescence-accelerated mouse (SAMP10). Ding, X., Yu, J., Yu, T., Fu, Y., Han, J. Neurosci. Lett. (2006) [Pubmed]
 
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