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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Krt6b  -  keratin 6B

Mus musculus

Synonyms: BB144589, CK-6B, Cytokeratin-6B, K6-beta, K6B, ...
 
 
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High impact information on Krt6b

  • Two functional genes, K6alpha and K6beta, exist in a head-to-tail tandem array in mouse genomes [1].
  • Introducing a null mutation in the mouse K6alpha and K6beta genes reveals their essential structural role in the oral mucosa [1].
  • Morphological analyses implicate the filiform papillae as being particularly sensitive to trauma in K6alpha/K6beta null mice, and establish the complete absence of keratin filaments in their anterior compartment [1].
  • Yet null alleles obliterating the function of both K6 genes (K6alpha and K6beta) or the K17 gene, as well as the targeted expression of a dominant-negative K6alpha mutant, elicit only a subset of PC-specific epithelial lesions (excluding that of the nail in mice) [2].
 

Anatomical context of Krt6b

  • We show that newborn mice null for K6alpha, K6beta, and K17 exhibit severe lysis restricted to the nail bed epithelium, where all three genes are robustly expressed, providing strong evidence that this region of the nail unit is initially targeted in PC [2].

References

  1. Introducing a null mutation in the mouse K6alpha and K6beta genes reveals their essential structural role in the oral mucosa. Wong, P., Colucci-Guyon, E., Takahashi, K., Gu, C., Babinet, C., Coulombe, P.A. J. Cell Biol. (2000) [Pubmed]
  2. Overcoming functional redundancy to elicit pachyonychia congenita-like nail lesions in transgenic mice. Wong, P., Domergue, R., Coulombe, P.A. Mol. Cell. Biol. (2005) [Pubmed]
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