Gene Review:
Arhgef2 - rho/rac guanine nucleotide exchange factor...
Mus musculus
Synonyms:
AA408978, GEF, GEF-H1, GEFH1, Guanine nucleotide exchange factor H1, ...
- Enteropathogenic Escherichia coli activates the RhoA signaling pathway via the stimulation of GEF-H1. Matsuzawa, T., Kuwae, A., Yoshida, S., Sasakawa, C., Abe, A. EMBO J. (2004)
- The guanine nucleotide exchange factor Tiam1 affects neuronal morphology; opposing roles for the small GTPases Rac and Rho. Leeuwen, F.N., Kain, H.E., Kammen, R.A., Michiels, F., Kranenburg, O.W., Collard, J.G. J. Cell Biol. (1997)
- The restoration of impaired macrophage functions using as immunomodulator the Corynebacterium granulosum-derived P40 fraction. Mastroeni, P., Bizzini, B., Bonina, L., Iannello, D., Merendino, R.A., Delfino, D., Berlinghieri, M.C., Leonardi, M.S., Arena, A., Liberto, M.C. Immunopharmacology (1985)
- The Corynebacterium granulosum-derived P40 immunomodulator exerts a synergistic effect on the activity of antiviral drugs in the treatment of experimental viral infections. Fattal-German, M., Bizzini, B. Biomed. Pharmacother. (1988)
- Further characterization of the in vitro products generated by proteolytic cleavage of Gazdar murine sarcoma virus p65gag. Maxwell, S.A., Arlinghaus, R.B. J. Gen. Virol. (1985)
- IgE-binding factors and regulation of the IgE antibody response. Ishizaka, K. Annu. Rev. Immunol. (1988)
- Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation. Aghazadeh, B., Lowry, W.E., Huang, X.Y., Rosen, M.K. Cell (2000)
- GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Rossman, K.L., Der, C.J., Sondek, J. Nat. Rev. Mol. Cell Biol. (2005)
- Autonomous growth and tumorigenicity induced by P40/interleukin 9 cDNA transfection of a mouse P40-dependent T cell line. Uyttenhove, C., Druez, C., Renauld, J.C., Hérin, M., Noël, H., Van Snick, J. J. Exp. Med. (1991)
- PAK4 mediates morphological changes through the regulation of GEF-H1. Callow, M.G., Zozulya, S., Gishizky, M.L., Jallal, B., Smeal, T. J. Cell. Sci. (2005)
- The Rho GTP exchange factor Lfc promotes spindle assembly in early mitosis. Bakal, C.J., Finan, D., LaRose, J., Wells, C.D., Gish, G., Kulkarni, S., DeSepulveda, P., Wilde, A., Rottapel, R. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Expression cloning of lfc, a novel oncogene with structural similarities to guanine nucleotide exchange factors and to the regulatory region of protein kinase C. Whitehead, I., Kirk, H., Tognon, C., Trigo-Gonzalez, G., Kay, R. J. Biol. Chem. (1995)
- The Rho-specific GEF Lfc interacts with neurabin and spinophilin to regulate dendritic spine morphology. Ryan, X.P., Alldritt, J., Svenningsson, P., Allen, P.B., Wu, G.Y., Nairn, A.C., Greengard, P. Neuron (2005)
- Modulation of muscle regeneration, myogenesis, and adipogenesis by the Rho family guanine nucleotide exchange factor GEFT. Bryan, B.A., Mitchell, D.C., Zhao, L., Ma, W., Stafford, L.J., Teng, B.B., Liu, M. Mol. Cell. Biol. (2005)
- The two guanine nucleotide exchange factor domains of Trio link the Rac1 and the RhoA pathways in vivo. Bellanger, J.M., Lazaro, J.B., Diriong, S., Fernandez, A., Lamb, N., Debant, A. Oncogene (1998)
- Lineage-specific requirement for the PH domain of Vav1 in the activation of CD4+ but not CD8+ T cells. Prisco, A., Vanes, L., Ruf, S., Trigueros, C., Tybulewicz, V.L. Immunity (2005)
- Functional and structural characterization of P40, a mouse glycoprotein with T-cell growth factor activity. Uyttenhove, C., Simpson, R.J., Van Snick, J. Proc. Natl. Acad. Sci. U.S.A. (1988)
- Regulation of mRNA utilization in mouse erythroleukemia cells induced to differentiate by exposure to dimethyl sulfoxide. Yenofsky, R., Cereghini, S., Krowczynska, A., Brawerman, G. Mol. Cell. Biol. (1983)
- The role of the C9b domain in the binding of C9 molecules to EAC1-8 defined by monoclonal antibodies to C9. Yoden, A., Moriyama, T., Inoue, K., Inai, S. J. Immunol. (1988)
- Oligomerization of DH domain is essential for Dbl-induced transformation. Zhu, K., Debreceni, B., Bi, F., Zheng, Y. Mol. Cell. Biol. (2001)
- The Dbl-related protein, Lfc, localizes to microtubules and mediates the activation of Rac signaling pathways in cells. Glaven, J.A., Whitehead, I., Bagrodia, S., Kay, R., Cerione, R.A. J. Biol. Chem. (1999)
- Distinct roles for the two Rho GDP/GTP exchange factor domains of kalirin in regulation of neurite growth and neuronal morphology. Penzes, P., Johnson, R.C., Kambampati, V., Mains, R.E., Eipper, B.A. J. Neurosci. (2001)
- Activation of RhoA and SAPK/JNK signalling pathways by the RhoA-specific exchange factor mNET1. Alberts, A.S., Treisman, R. EMBO J. (1998)
- Regulation of proto-Dbl by intracellular membrane targeting and protein stability. Vanni, C., Mancini, P., Gao, Y., Ottaviano, C., Guo, F., Salani, B., Torrisi, M.R., Zheng, Y., Eva, A. J. Biol. Chem. (2002)
- Dynamic and coordinated expression profile of dbl-family guanine nucleotide exchange factors in the developing mouse brain. Yoshizawa, M., Sone, M., Matsuo, N., Nagase, T., Ohara, O., Nabeshima, Y., Hoshino, M. Gene Expr. Patterns (2003)
- Identification of a tight junction-associated guanine nucleotide exchange factor that activates Rho and regulates paracellular permeability. Benais-Pont, G., Punn, A., Flores-Maldonado, C., Eckert, J., Raposo, G., Fleming, T.P., Cereijido, M., Balda, M.S., Matter, K. J. Cell Biol. (2003)
- Subunit assembly and guanine nucleotide exchange activity of eukaryotic initiation factor-2B expressed in Sf9 cells. Fabian, J.R., Kimball, S.R., Heinzinger, N.K., Jefferson, L.S. J. Biol. Chem. (1997)
- Mutations at position 1122 in the catalytic domain of the mouse ras-specific guanine nucleotide exchange factor CDC25Mm originate both loss-of-function and gain-of-function proteins. Carrera, V., Moroni, A., Martegani, E., Volponi, C., Cool, R.H., Alberghina, L., Vanoni, M. FEBS Lett. (1998)