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Gene Review

ll  -  long lived

Mus musculus

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  • Long-lived dwarf mice share many phenotypic characteristics with genetically normal (wild-type) animals subjected to prolonged caloric restriction (CR) but are not CR mimetics [21].
  • Long-lived binding of gp70 onto surfaces of uninfected cells may explain important features of viral-induced leukemia, the host immune response, and immunosuppression [22].


  1. An autosomal recessive gene that delays expression of lupus in BXSB mice. Kofler, R., McConahey, P.J., Duchosal, M.A., Balderas, R.S., Theofilopoulos, A.N., Dixon, F.J. J. Immunol. (1991) [Pubmed]
  2. IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Holzenberger, M., Dupont, J., Ducos, B., Leneuve, P., Géloën, A., Even, P.C., Cervera, P., Le Bouc, Y. Nature (2003) [Pubmed]
  3. Long-lived signal peptide of lymphocytic choriomeningitis virus glycoprotein pGP-C. Froeschke, M., Basler, M., Groettrup, M., Dobberstein, B. J. Biol. Chem. (2003) [Pubmed]
  4. Long-lived respiratory immune response to filamentous hemagglutinin following Bordetella pertussis infection. Amsbaugh, D.F., Li, Z.M., Shahin, R.D. Infect. Immun. (1993) [Pubmed]
  5. BCMA is essential for the survival of long-lived bone marrow plasma cells. O'Connor, B.P., Raman, V.S., Erickson, L.D., Cook, W.J., Weaver, L.K., Ahonen, C., Lin, L.L., Mantchev, G.T., Bram, R.J., Noelle, R.J. J. Exp. Med. (2004) [Pubmed]
  6. Long-lived cytotoxic T lymphocyte memory in mucosal tissues after mucosal but not systemic immunization. Gallichan, W.S., Rosenthal, K.L. J. Exp. Med. (1996) [Pubmed]
  7. IgG plasma cells display a unique spectrum of leukocyte adhesion and homing molecules. Underhill, G.H., Minges Wols, H.A., Fornek, J.L., Witte, P.L., Kansas, G.S., Minges-Wols, H.A. Blood (2002) [Pubmed]
  8. Priming with Cold-Adapted Influenza A Does Not Prevent Infection but Elicits Long-Lived Protection against Supralethal Challenge with Heterosubtypic Virus. Powell, T.J., Strutt, T., Reome, J., Hollenbaugh, J.A., Roberts, A.D., Woodland, D.L., Swain, S.L., Dutton, R.W. J. Immunol. (2007) [Pubmed]
  9. Nature of "memory" in T-cell mediated antibacterial immunity: cellular parameters that distinguish between the active immune response and a state of "memory". North, R.J., Deissler, J.F. Infect. Immun. (1975) [Pubmed]
  10. Long-lived {alpha}MUPA transgenic mice exhibit pronounced circadian rhythms. Froy, O., Chapnik, N., Miskin, R. Am. J. Physiol. Endocrinol. Metab. (2006) [Pubmed]
  11. Long-lived mutagenic radicals induced in mammalian cells by ionizing radiation are mainly localized to proteins. Kumagai, J., Masui, K., Itagaki, Y., Shiotani, M., Kodama, S., Watanabe, M., Miyazaki, T. Radiat. Res. (2003) [Pubmed]
  12. Cassette-based presentation of SIV epitopes with recombinant gas vesicles from halophilic archaea. Stuart, E.S., Morshed, F., Sremac, M., Dassarma, S. J. Biotechnol. (2004) [Pubmed]
  13. Long-lived growth hormone receptor knockout mice show a delay in age-related changes of body composition and bone characteristics. Bonkowski, M.S., Pamenter, R.W., Rocha, J.S., Masternak, M.M., Panici, J.A., Bartke, A. J. Gerontol. A Biol. Sci. Med. Sci. (2006) [Pubmed]
  14. Long-lived alphaMUPA transgenic mice show reduced SOD2 expression, enhanced apoptosis and reduced susceptibility to the carcinogen dimethylhydrazine. Tirosh, O., Pardo, M., Schwartz, B., Miskin, R. Mech. Ageing Dev. (2005) [Pubmed]
  15. Relaxed negative selection in germinal centers and impaired affinity maturation in bcl-xL transgenic mice. Takahashi, Y., Cerasoli, D.M., Dal Porto, J.M., Shimoda, M., Freund, R., Fang, W., Telander, D.G., Malvey, E.N., Mueller, D.L., Behrens, T.W., Kelsoe, G. J. Exp. Med. (1999) [Pubmed]
  16. Repertoires of T cell receptors expressed by graft-infiltrating T cells evolve during long-term recall responses to single minor histocompatibility antigens. Wettstein, P.J., Strausbauch, M., Borson, N. Int. Immunol. (2007) [Pubmed]
  17. Long-lived T and B lymphocytes in the bone marrow and thoracic duct lymph of the mouse. Röpke, C., Hougen, H.P., Everett, N.B. Cell. Immunol. (1975) [Pubmed]
  18. Methionine flux to transsulfuration is enhanced in the long living Ames dwarf mouse. Uthus, E.O., Brown-Borg, H.M. Mech. Ageing Dev. (2006) [Pubmed]
  19. Long-lived Ames dwarf mouse exhibits increased antioxidant defense in skeletal muscle. Romanick, M.A., Rakoczy, S.G., Brown-Borg, H.M. Mech. Ageing Dev. (2004) [Pubmed]
  20. Long-lived positron emitters zirconium-89 and iodine-124 for scouting of therapeutic radioimmunoconjugates with PET. Verel, I., Visser, G.W., Boerman, O.C., van Eerd, J.E., Finn, R., Boellaard, R., Vosjan, M.J., Stigter-van Walsum, M., Snow, G.B., van Dongen, G.A. Cancer Biother. Radiopharm. (2003) [Pubmed]
  21. Life extension in the dwarf mouse. Bartke, A., Brown-Borg, H. Curr. Top. Dev. Biol. (2004) [Pubmed]
  22. Cell surface receptors for ecotropic murine retroviruses: mobile membrane proteins that mediate binding and slow endocytosis of the viral envelope glycoprotein. Kabat, D. Virology (1989) [Pubmed]
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