Gene Review:
Lum - lumican
Mus musculus
Synonyms:
KSPG lumican, Keratan sulfate proteoglycan lumican, Lcn, Ldc, Lumican, ...
- A syndrome of joint laxity and impaired tendon integrity in lumican- and fibromodulin-deficient mice. Jepsen, K.J., Wu, F., Peragallo, J.H., Paul, J., Roberts, L., Ezura, Y., Oldberg, A., Birk, D.E., Chakravarti, S. J. Biol. Chem. (2002)
- Ocular and scleral alterations in gene-targeted lumican-fibromodulin double-null mice. Chakravarti, S., Paul, J., Roberts, L., Chervoneva, I., Oldberg, A., Birk, D.E. Invest. Ophthalmol. Vis. Sci. (2003)
- Lumican regulates collagen fibril assembly: skin fragility and corneal opacity in the absence of lumican. Chakravarti, S., Magnuson, T., Lass, J.H., Jepsen, K.J., LaMantia, C., Carroll, H. J. Cell Biol. (1998)
- Sequence, molecular properties, and chromosomal mapping of mouse lumican. Funderburgh, J.L., Funderburgh, M.L., Hevelone, N.D., Stech, M.E., Justice, M.J., Liu, C.Y., Kao, W.W., Conrad, G.W. Invest. Ophthalmol. Vis. Sci. (1995)
- Keratocan and lumican regulate neutrophil infiltration and corneal clarity in lipopolysaccharide-induced keratitis by direct interaction with CXCL1. Carlson, E.C., Lin, M., Liu, C.Y., Kao, W.W., Perez, V.L., Pearlman, E. J. Biol. Chem. (2007)
- Eating oneself and uninvited guests: autophagy-related pathways in cellular defense. Levine, B. Cell (2005)
- Differential expression of lumican and fibromodulin regulate collagen fibrillogenesis in developing mouse tendons. Ezura, Y., Chakravarti, S., Oldberg, A., Chervoneva, I., Birk, D.E. J. Cell Biol. (2000)
- Lumican suppresses cell proliferation and aids Fas-Fas ligand mediated apoptosis: implications in the cornea. Vij, N., Roberts, L., Joyce, S., Chakravarti, S. Exp. Eye Res. (2004)
- Exclusion of lumican and fibromodulin as candidate genes in MYP3 linked high grade myopia. Paluru, P.C., Scavello, G.S., Ganter, W.R., Young, T.L. Mol. Vis. (2004)
- Keratocan, a cornea-specific keratan sulfate proteoglycan, is regulated by lumican. Carlson, E.C., Liu, C.Y., Chikama, T., Hayashi, Y., Kao, C.W., Birk, D.E., Funderburgh, J.L., Jester, J.V., Kao, W.W. J. Biol. Chem. (2005)
- Fibromodulin-null murine knee joints display increased incidences of osteoarthritis and alterations in tissue biochemistry. Gill, M.R., Oldberg, A., Reinholt, F.P. Osteoarthr. Cartil. (2002)
- Functions of lumican and fibromodulin: lessons from knockout mice. Chakravarti, S. Glycoconj. J. (2002)
- Role of Cys41 in the N-terminal domain of lumican in ex vivo collagen fibrillogenesis by cultured corneal stromal cells. Carlson, E.C., Mamiya, K., Liu, C.Y., Gendron, R.L., Birk, D.E., Funderburgh, J.L., Kao, W.W. Biochem. J. (2003)
- A novel role of the lumican core protein in bacterial lipopolysaccharide-induced innate immune response. Wu, F., Vij, N., Roberts, L., Lopez-Briones, S., Joyce, S., Chakravarti, S. J. Biol. Chem. (2007)
- Lumican regulates corneal inflammatory responses by modulating Fas-Fas ligand signaling. Vij, N., Roberts, L., Joyce, S., Chakravarti, S. Invest. Ophthalmol. Vis. Sci. (2005)
- Small leucine-rich proteoglycans (SLRPs) in uterine tissues during pregnancy in mice. San Martin, S., Soto-Suazo, M., De Oliveira, S.F., Aplin, J.D., Abrahamsohn, P., Zorn, T.M. Reproduction (2003)
- TGFbeta2 in corneal morphogenesis during mouse embryonic development. Saika, S., Saika, S., Liu, C.Y., Azhar, M., Sanford, L.P., Doetschman, T., Gendron, R.L., Kao, C.W., Kao, W.W. Dev. Biol. (2001)
- Characterization and expression of the mouse lumican gene. Ying, S., Shiraishi, A., Kao, C.W., Converse, R.L., Funderburgh, J.L., Swiergiel, J., Roth, M.R., Conrad, G.W., Kao, W.W. J. Biol. Chem. (1997)
- Corneal opacity in lumican-null mice: defects in collagen fibril structure and packing in the posterior stroma. Chakravarti, S., Petroll, W.M., Hassell, J.R., Jester, J.V., Lass, J.H., Paul, J., Birk, D.E. Invest. Ophthalmol. Vis. Sci. (2000)
- Lumican is a major proteoglycan component of the bone matrix. Raouf, A., Ganss, B., McMahon, C., Vary, C., Roughley, P.J., Seth, A. Matrix Biol. (2002)