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Lxn  -  latexin

Mus musculus

Synonyms: ECI, Endogenous carboxypeptidase inhibitor, Latexin, TCI, Tissue carboxypeptidase inhibitor
 
 
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Disease relevance of Lxn

  • Two systems have been examined for delivery of DNA-vaccine encoding a HIV-1 polyepitope CTL-immunogen (TCI) [1].
  • Female BALB/c mice were immunized with tetanus toxoid (TT) admixed with cholera toxin by direct application to shaved skin (Transcutaneous immunization, TCI) [2].
 

High impact information on Lxn

 

Anatomical context of Lxn

  • Latexin, the endogenous protein inhibitor of the A/B subfamily of metallocarboxypeptidases, is expressed in small nociceptive neurons in sensory ganglia and in a subset of neurons in the telencephalon [5].
  • Latexin is expressed in the developing brain, and we find that it plays a role in inflammation, as it is expressed at high levels and is inducible in macrophages in concert with other protease inhibitors and potential protease targets [6].
 

Analytical, diagnostic and therapeutic context of Lxn

  • Using oligonucleotide arrays, real-time PCR and protein blots, we identified latexin (Lxn), a gene whose differential transcription and expression was associated with the allelic differences [3].
  • TCI elicited significant levels of TT-specific IgG in serum, saliva and vaginal lavage, with the greatest increases over background seen in saliva (80-400 fold) and vaginal lavage (2-87 fold) [2].

References

  1. Comparative analysis using a mouse model of the immunogenicity of artificial VLP and attenuated Salmonella strain carrying a DNA-vaccine encoding HIV-1 polyepitope CTL-immunogen. Karpenko, L.I., Nekrasova, N.A., Ilyichev, A.A., Lebedev, L.R., Ignatyev, G.M., Agafonov, A.P., Zaitsev, B.N., Belavin, P.A., Seregin, S.V., Danilyuk, N.K., Babkina, I.N., Bazhan, S.I. Vaccine (2004) [Pubmed]
  2. Transcutaneous immunization induces mucosal and systemic immunity: a potent method for targeting immunity to the female reproductive tract. Gockel, C.M., Bao, S., Beagley, K.W. Mol. Immunol. (2000) [Pubmed]
  3. The quantitative trait gene latexin influences the size of the hematopoietic stem cell population in mice. Liang, Y., Jansen, M., Aronow, B., Geiger, H., Van Zant, G. Nat. Genet. (2007) [Pubmed]
  4. Mapping to mouse chromosome 3 of the gene encoding latexin (Lxn) expressed in neocortical neurons in a region-specific manner. Jin, M., Uratani, Y., Arimatsu, Y. Genomics (1997) [Pubmed]
  5. Reduced pain sensitivity in mice lacking latexin, an inhibitor of metallocarboxypeptidases. Jin, M., Ishida, M., Katoh-Fukui, Y., Tsuchiya, R., Higashinakagawa, T., Ikegami, S., Arimatsu, Y. Brain Res. (2006) [Pubmed]
  6. An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: relationship to cystatins and the tumor suppressor TIG1. Aagaard, A., Listwan, P., Cowieson, N., Huber, T., Ravasi, T., Wells, C.A., Flanagan, J.U., Kellie, S., Hume, D.A., Kobe, B., Martin, J.L. Structure (Camb.) (2005) [Pubmed]
 
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