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Gene Review

pknox1.1  -  pbx/knotted 1 homeobox 1.1

Danio rerio

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High impact information on pknox1.1

  • Furthermore, the heads of prep1.1 morphants lacked all pharyngeal cartilages [1].
  • Morpholino-induced prep1.1 loss-of-function caused significant apoptosis in the CNS [1].
  • Our results indicate that prep1.1 has a unique genetic function in craniofacial chondrogenesis and, acting as a member of Meinox-Pbc-Hox trimers, it plays an essential role in hindbrain development [1].
 

Analytical, diagnostic and therapeutic context of pknox1.1

  • In situ hybridization showed that prep1.1 is expressed maternally and ubiquitously up to 24 hours post-fertilization (hpf), and restricted to the head from 48 hpf onwards [1].

References

  1. Prep1.1 has essential genetic functions in hindbrain development and cranial neural crest cell differentiation. Deflorian, G., Tiso, N., Ferretti, E., Meyer, D., Blasi, F., Bortolussi, M., Argenton, F. Development (2004) [Pubmed]
 
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