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Gene Review

Tlr7  -  toll-like receptor 7

Mus musculus

Synonyms: Toll-like receptor 7
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Disease relevance of Tlr7


High impact information on Tlr7


Biological context of Tlr7


Anatomical context of Tlr7

  • These results identify ssRNA as a ligand for TLR7 and suggest that cells of the innate immune system sense endosomal ssRNA to detect infection by RNA viruses [10].
  • Immunohistochemical analysis of livers shows that TLR7 is expressed in hepatocytes of normal or HCV-infected people [9].
  • RESULTS: HSP70 binds Toll-like receptor-7 (TLR7) on the lipid raft microdomain of macrophage plasma membrane [11].

Associations of Tlr7 with chemical compounds

  • Prolonged exposure of Huh-7 cells to a TLR7 ligand [SM360320 (9-benzyl-8-hydroxy-2-(2-methoxyethoxy)adenine)], alone or in combination with an inosine monophosphate dehydrogenase inhibitor, reduced HCV levels dose dependently [9].
  • Nucleic acid agonists for Toll-like receptor 7 are defined by the presence of uridine ribonucleotides [12].

Regulatory relationships of Tlr7


  1. A Tlr7 translocation accelerates systemic autoimmunity in murine lupus. Subramanian, S., Tus, K., Li, Q.Z., Wang, A., Tian, X.H., Zhou, J., Liang, C., Bartov, G., McDaniel, L.D., Zhou, X.J., Schultz, R.A., Wakeland, E.K. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  2. Recognition of single-stranded RNA viruses by Toll-like receptor 7. Lund, J.M., Alexopoulou, L., Sato, A., Karow, M., Adams, N.C., Gale, N.W., Iwasaki, A., Flavell, R.A. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  3. Ikaros is required for plasmacytoid dendritic cell differentiation. Allman, D., Dalod, M., Asselin-Paturel, C., Delale, T., Robbins, S.H., Trinchieri, G., Biron, C.A., Kastner, P., Chan, S. Blood (2006) [Pubmed]
  4. Dendritic cells respond to influenza virus through TLR7- and PKR-independent pathways. Barchet, W., Krug, A., Cella, M., Newby, C., Fischer, J.A., Dzionek, A., Pekosz, A., Colonna, M. Eur. J. Immunol. (2005) [Pubmed]
  5. Toll-like Receptor 7 and TLR9 Dictate Autoantibody Specificity and Have Opposing Inflammatory and Regulatory Roles in a Murine Model of Lupus. Christensen, S.R., Shupe, J., Nickerson, K., Kashgarian, M., Flavell, R.A., Shlomchik, M.J. Immunity (2006) [Pubmed]
  6. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Hemmi, H., Kaisho, T., Takeuchi, O., Sato, S., Sanjo, H., Hoshino, K., Horiuchi, T., Tomizawa, H., Takeda, K., Akira, S. Nat. Immunol. (2002) [Pubmed]
  7. RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. Lau, C.M., Broughton, C., Tabor, A.S., Akira, S., Flavell, R.A., Mamula, M.J., Christensen, S.R., Shlomchik, M.J., Viglianti, G.A., Rifkin, I.R., Marshak-Rothstein, A. J. Exp. Med. (2005) [Pubmed]
  8. Role of SLC11A1 (formerly NRAMP1) in regulation of signal transduction induced by Toll-like receptor 7 ligands. Moisan, J., Thuraisingam, T., Henault, J., De Sanctis, J., Radzioch, D. FEMS Immunol. Med. Microbiol. (2006) [Pubmed]
  9. Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Lee, J., Wu, C.C., Lee, K.J., Chuang, T.H., Katakura, K., Liu, Y.T., Chan, M., Tawatao, R., Chung, M., Shen, C., Cottam, H.B., Lai, M.M., Raz, E., Carson, D.A. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  10. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Diebold, S.S., Kaisho, T., Hemmi, H., Akira, S., Reis e Sousa, C. Science (2004) [Pubmed]
  11. HSP70 Enhances Macrophage Phagocytosis by Interaction With Lipid Raft-Associated TLR-7 and Upregulating p38 MAPK and PI3K Pathways. Wang, R., Town, T., Gokarn, V., Flavell, R.A., Chandawarkar, R.Y. J. Surg. Res. (2006) [Pubmed]
  12. Nucleic acid agonists for Toll-like receptor 7 are defined by the presence of uridine ribonucleotides. Diebold, S.S., Massacrier, C., Akira, S., Paturel, C., Morel, Y., Reis E Sousa, C. Eur. J. Immunol. (2006) [Pubmed]
  13. Requirement of Toll-like receptor 7 for pristane-induced production of autoantibodies and development of murine lupus nephritis. Savarese, E., Steinberg, C., Pawar, R.D., Reindl, W., Akira, S., Anders, H.J., Krug, A. Arthritis Rheum. (2008) [Pubmed]
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