Disease relevance of Tlr7

• A Tlr7 translocation accelerates systemic autoimmunity in murine lupus [1].
• Recognition of single-stranded RNA viruses by Toll-like receptor 7 [2].
• Loss of pDCs is associated with an inability to produce type I IFN after challenge with Toll-like receptor-7 and -9 ligands, or murine cytomegalovirus (MCMV) infection [3].
• To address this, we compared the DC and IPC responses to influenza virus and ssRNA oligoribonucleotides (ORN) that activate TLR7 [4].

High impact information on Tlr7

• Toll-like Receptor 7 and TLR9 Dictate Autoantibody Specificity and Have Opposing Inflammatory and Regulatory Roles in a Murine Model of Lupus [5].
• In response to the imidazoquinolines, neither MyD88- nor TLR7-deficient mice showed any inflammatory cytokine production by macrophages, proliferation of splenocytes or maturation of dendritic cells [6].
• RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement [7].
• The resulting overexpression of Tlr7 increased in vitro responses to Toll-like receptor (TLR) 7 signaling in all yaa-bearing males [1].
• Transcription profiling of yaa-bearing B cells revealed the overexpression of a cluster of X-linked genes that included Tlr7 [1].

Biological context of Tlr7

• Role of SLC11A1 (formerly NRAMP1) in regulation of signal transduction induced by Toll-like receptor 7 ligands [8].
• Human hepatocyte line Huh-7 carrying an HCV replicon expressed TLR7, and activation of the receptor induced several antiviral genes including IFN regulatory factor-7 [9].

Anatomical context of Tlr7

• These results identify ssRNA as a ligand for TLR7 and suggest that cells of the innate immune system sense endosomal ssRNA to detect infection by RNA viruses [10].
• Immunohistochemical analysis of livers shows that TLR7 is expressed in hepatocytes of normal or HCV-infected people [9].
• RESULTS: HSP70 binds Toll-like receptor-7 (TLR7) on the lipid raft microdomain of macrophage plasma membrane [11].

Associations of Tlr7 with chemical compounds

• Prolonged exposure of Huh-7 cells to a TLR7 ligand [SM360320 (9-benzyl-8-hydroxy-2-(2-methoxyethoxy)adenine)], alone or in combination with an inosine monophosphate dehydrogenase inhibitor, reduced HCV levels dose dependently [9].
• Nucleic acid agonists for Toll-like receptor 7 are defined by the presence of uridine ribonucleotides [12].

Regulatory relationships of Tlr7

• We found that anti-snRNP antibody production induced by pristane treatment was entirely dependent on the expression of TLR-7, whereas anti-double-stranded DNA antibody production was not affected by a lack of TLR-7 [13].

References