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Ucn2  -  urocortin 2

Rattus norvegicus

Synonyms: Ucn II, Urocortin II, Urocortin-2
 
 
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Disease relevance of Ucn2

 

Psychiatry related information on Ucn2

  • Effects of urocortin 2 and 3 on motor activity and food intake in rats [2].
  • Urocortin 2 actions on serotonergic systems described here may contribute to delayed behavioral effects of urocortin 2 described previously, including orexigenic, locomotor, and anxiety-related effects in a variety of behavioral tests as well as potentiation of conditioned fear and induction of escape deficits in a model of learned helplessness [3].
 

High impact information on Ucn2

 

Biological context of Ucn2

 

Anatomical context of Ucn2

 

Associations of Ucn2 with chemical compounds

  • Prazosin abolished the intracisternal Ucn 2 inhibitory effect, whereas yohimbine and propranolol did not [8].
  • Ucn II (3, 10, and 30 microg/kg, i.v.) did not alter the 20 min net rise in MAP induced by RX-77368 (35.7+/-7.1, 32.6+/-3.3 and 24.6+/-6.9 mm Hg, respectively) compared with vehicle (33.6+/-4.3 mm Hg) [9].
  • Intra-DRN Ucn 2 also increased c-fos expression in labeled 5-HT neurons [14].
  • Treatment with Ucn 2 increased noradrenaline secretion and induced phosphorylation of PKA and Erk1/2 [1].
  • Antisauvagine-30, but not antalarmin, antagonized UII, implicating CRF-R2 receptors in the effects [15].
 

Regulatory relationships of Ucn2

  • Ucn 2 attenuated the inhibition of locomotor activity induced by CRF without affecting other activities, such as rearing or grooming behavior [2].
 

Other interactions of Ucn2

 

Analytical, diagnostic and therapeutic context of Ucn2

  • High-performance liquid chromatography analysis of hypothalamic, pituitary, and adrenal extracts showed that the main Ucn 2-LI peak occurred at the same molecular size as that of synthetic Ucn 2 [12].

References

  1. Urocortin 2 induces tyrosine hydroxylase phosphorylation in PC12 cells. Nemoto, T., Mano-Otagiri, A., Shibasaki, T. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  2. Effects of urocortin 2 and 3 on motor activity and food intake in rats. Ohata, H., Shibasaki, T. Peptides (2004) [Pubmed]
  3. Urocortin 2 increases c-Fos expression in topographically organized subpopulations of serotonergic neurons in the rat dorsal raphe nucleus. Staub, D.R., Spiga, F., Lowry, C.A. Brain Res. (2005) [Pubmed]
  4. Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors. Reyes, T.M., Lewis, K., Perrin, M.H., Kunitake, K.S., Vaughan, J., Arias, C.A., Hogenesch, J.B., Gulyas, J., Rivier, J., Vale, W.W., Sawchenko, P.E. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  5. Effect of central corticotropin releasing factor on hepatic circulation in rats: the role of the CRF2 receptor in the brain. Yoneda, M., Nakamura, K., Nakade, Y., Tamano, M., Kono, T., Watanobe, H., Shimada, T., Hiraishi, H., Terano, A. Gut (2005) [Pubmed]
  6. Role of corticotropin-releasing factor receptor-2 in stress-induced suppression of pulsatile luteinizing hormone secretion in the rat. Li, X.F., Bowe, J.E., Lightman, S.L., O'Byrne, K.T. Endocrinology (2005) [Pubmed]
  7. Urocortin-related peptides increase interleukin-6 output via cyclic adenosine 5'-monophosphate-dependent pathways in A7r5 aortic smooth muscle cells. Kageyama, K., Suda, T. Endocrinology (2003) [Pubmed]
  8. Urocortin 2 acts centrally to delay gastric emptying through sympathetic pathways while CRF and urocortin 1 inhibitory actions are vagal dependent in rats. Czimmer, J., Million, M., Taché, Y. Am. J. Physiol. Gastrointest. Liver Physiol. (2006) [Pubmed]
  9. Intravenous urocortin II decreases blood pressure through CRF(2) receptor in rats. Chen, C.Y., Doong, M.L., Rivier, J.E., Taché, Y. Regul. Pept. (2003) [Pubmed]
  10. Urocortin, but not urocortin II, protects cultured hippocampal neurons from oxidative and excitotoxic cell death via corticotropin-releasing hormone receptor type I. Pedersen, W.A., Wan, R., Zhang, P., Mattson, M.P. J. Neurosci. (2002) [Pubmed]
  11. Human urocortin 2, a corticotropin-releasing factor (CRF)2 agonist, and ovine CRF, a CRF1 agonist, differentially alter feeding and motor activity. Zorrilla, E.P., Reinhardt, L.E., Valdez, G.R., Inoue, K., Rivier, J.E., Vale, W.W., Koob, G.F. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
  12. Distribution of urocortin 2 in various tissues of the rat. Yamauchi, N., Otagiri, A., Nemoto, T., Sekino, A., Oono, H., Kato, I., Yanaihara, C., Shibasaki, T. J. Neuroendocrinol. (2005) [Pubmed]
  13. Effects of urocortin II on neonatal rat cardiac myocytes and non-myocytes. Ikeda, K., Tojo, K., Otsubo, C., Udagawa, T., Hosoya, T., Tajima, N., Nakao, K., Kawamura, M. Peptides (2005) [Pubmed]
  14. Microinjection of urocortin 2 into the dorsal raphe nucleus activates serotonergic neurons and increases extracellular serotonin in the basolateral amygdala. Amat, J., Tamblyn, J.P., Paul, E.D., Bland, S.T., Amat, P., Foster, A.C., Watkins, L.R., Maier, S.F. Neuroscience (2004) [Pubmed]
  15. Selective activation of corticotropin-releasing factor-2 receptors on neurochemically identified neurons in the rat dorsal raphe nucleus reveals dual actions. Pernar, L., Curtis, A.L., Vale, W.W., Rivier, J.E., Valentino, R.J. J. Neurosci. (2004) [Pubmed]
 
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