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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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About

Terms

 

Gene Review: 

Cry2  -  cryptochrome circadian clock 2

Rattus norvegicus

Synonyms: Cryptochrome-2
 
 
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Disease relevance of Cry2

  • Ischemia-reperfusion leads to a persistent decrease of Per1 and Cry2, which may be related to the selective degeneration of amacrine and ganglion cells [1].
 

High impact information on Cry2

  • Because of the peculiar role of the pineal gland in the photoneuroendocrine axis regulating biological rhythms, we studied whether clock genes are expressed in the rat pineal gland and how their expression is regulated.Per1, Per3, Cry2 and Cry1 clock genes are expressed in the pineal gland and their transcription is increased during the night [2].
  • These results suggest that Cry1 in the pineal gland is regulated by photic and circadian information but Cry2 is only regulated by circadian information [3].
  • Northern blot revealed that the expression of Cry2 mRNA was significantly decreased in the SCN of estrogen-treated rats at both time points [correction] [4].
 

Biological context of Cry2

 

Anatomical context of Cry2

 

Other interactions of Cry2

  • But the amplitude of the Cry1 rhythm was higher than that of the Cry2 rhythm [3].

References

  1. Circadian expression of clock genes and clock-controlled genes in the rat retina. Kamphuis, W., Cailotto, C., Dijk, F., Bergen, A., Buijs, R.M. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  2. Daily rhythm and regulation of clock gene expression in the rat pineal gland. Simonneaux, V., Poirel, V.J., Garidou, M.L., Nguyen, D., Diaz-Rodriguez, E., Pévet, P. Brain Res. Mol. Brain Res. (2004) [Pubmed]
  3. Circadian and photic regulation of cryptochrome mRNAs in the rat pineal gland. Nakamura, T.J., Shinohara, K., Funabashi, T., Mitsushima, D., Kimura, F. Neurosci. Res. (2001) [Pubmed]
  4. Effect of estrogen on the expression of Cry1 and Cry2 mRNAs in the suprachiasmatic nucleus of female rats. Nakamura, T.J., Shinohara, K., Funabashi, T., Kimura, F. Neurosci. Res. (2001) [Pubmed]
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