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Gene Review

Pacs1  -  phosphofurin acidic cluster sorting protein 1

Rattus norvegicus

Synonyms: PACS-1, Phosphofurin acidic cluster sorting protein 1
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High impact information on Pacs1

  • We found five transporter transcripts, the phosphonate transport ATPase PHNC, multidrug transporter homolog MTH104, protein-export-membrane protein SECD, oligopeptide transporters oppA and oppD, in the brain and two: ABC-transporter BRAF-2 and cation-transport ATPase PACS, in the heart [1].
  • The conclusion is made that at small, close to physiological doses of hydrocortisone (100 and 300 micrograms/100 g b.w.) the PACS inhibition is ensured by PVN involvement into the feedback pathways [2].
  • PACS and adrenal responses were estimated by the corticosterone content in blood [3].
  • The role of the paraventricular nucleus (PVN) of the hypothalamus and the hypophysis in ensuring the corticosteroid feedback of the pituitary-adrenocortical system (PACS) in rats was characterized by administration of increasing doses of hydrocortisone [2].
  • The conclusion was made that adrenal glands were involved in ensuring the feedback only at high doses of corticosteroids, contribution making up only a part of that discovered in PACS inhibition [3].

Anatomical context of Pacs1

  • The involvement of the hypothalamus in ensuring the corticosteroid feedback was estimated by the suppression of the stress-induced PACS reaction in animals with bilateral PVN lesions [2].


  1. Taurine modulates expression of transporters in rat brain and heart. Labudova, O., Yeghiazarjan, C., Höger, H., Lubec, G. Amino Acids (1999) [Pubmed]
  2. Corticosteroid feedback: II. Role of hypothalamus and hypophysis. Filaretov, A.A., Balashov YuG, n.u.l.l., Yarushkina, N.I., Podvigina, T.T. Exp. Clin. Endocrinol. (1988) [Pubmed]
  3. Corticosteroid feedback: I. General characteristics, role of adrenal cortex. Filaretov, A.A., Balashov YuG, n.u.l.l. Exp. Clin. Endocrinol. (1988) [Pubmed]
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