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Gene Review

Mbd2  -  methyl-CpG binding domain protein 2

Mus musculus

Synonyms: MBD2a, Methyl-CpG-binding domain protein 2, Methyl-CpG-binding protein MBD2
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Disease relevance of Mbd2

  • As Mbd2-deficient mice are viable and fertile, their resistance to intestinal cancer may be of therapeutic relevance [1].

Psychiatry related information on Mbd2


High impact information on Mbd2

  • We show by gene targeting that the two proteins are not functionally redundant in mice, as Mbd3-/- mice die during early embryogenesis, whereas Mbd2-/- mice are viable and fertile [2].
  • We examined cells lacking methyl CpG binding domain protein-2 (MBD2), a molecule that has been proposed to link DNA methylation to silent chromatin [3].
  • Impaired Memory CD8 T Cell Development in the Absence of Methyl-CpG-Binding Domain Protein 2 [4].
  • Methyl-CpG-binding domain protein 2 (MBD2) is a transcriptional repressor that binds to methylated DNA and mediates the biological consequences of epigenetic gene methylation [4].
  • In the present study, we show that inactivation of the Mbd2 gene, which links DNA methylation and repressed chromatin, results in enhanced resistance to the protozoan parasite Leishmania major but impaired immunity to the intestinal helminth Trichuris muris [5].

Anatomical context of Mbd2


  1. Deficiency of Mbd2 suppresses intestinal tumorigenesis. Sansom, O.J., Berger, J., Bishop, S.M., Hendrich, B., Bird, A., Clarke, A.R. Nat. Genet. (2003) [Pubmed]
  2. Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development. Hendrich, B., Guy, J., Ramsahoye, B., Wilson, V.A., Bird, A. Genes Dev. (2001) [Pubmed]
  3. Gene silencing quantitatively controls the function of a developmental trans-activator. Hutchins, A.S., Mullen, A.C., Lee, H.W., Sykes, K.J., High, F.A., Hendrich, B.D., Bird, A.P., Reiner, S.L. Mol. Cell (2002) [Pubmed]
  4. Impaired Memory CD8 T Cell Development in the Absence of Methyl-CpG-Binding Domain Protein 2. Kersh, E.N. J. Immunol. (2006) [Pubmed]
  5. Cutting edge: a critical role for gene silencing in preventing excessive type 1 immunity. Hutchins, A.S., Artis, D., Hendrich, B.D., Bird, A.P., Scott, P., Reiner, S.L. J. Immunol. (2005) [Pubmed]
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