The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • SNPedia

Table of contents

About

Terms

 

Gene Review: 

unc-11  -  Protein UNC-11

Caenorhabditis elegans

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on unc-11

  • By contrast, overexpression of ubiquitin decreased the abundance of GLR-1 at synapses and decreased the density of GLR-1-containing synapses, and these effects were prevented by mutations in the unc-11 gene, which encodes a clathrin adaptin protein (AP180) [1].
  • In neurons, UNC-11 is enriched at presynaptic terminals but is also present in cell bodies. unc-11 mutants are defective in two aspects of synaptic vesicle biogenesis [2].
  • We have now identified 3 more such genes (unc-63, unc-11 and unc-64) [3].
  • The gene maps on LGI, 0.4 map units from dpy-5 on the unc-11 side [4].

References

  1. Ubiquitin and AP180 regulate the abundance of GLR-1 glutamate receptors at postsynaptic elements in C. elegans. Burbea, M., Dreier, L., Dittman, J.S., Grunwald, M.E., Kaplan, J.M. Neuron (2002) [Pubmed]
  2. UNC-11, a Caenorhabditis elegans AP180 homologue, regulates the size and protein composition of synaptic vesicles. Nonet, M.L., Holgado, A.M., Brewer, F., Serpe, C.J., Norbeck, B.A., Holleran, J., Wei, L., Hartwieg, E., Jorgensen, E.M., Alfonso, A. Mol. Biol. Cell (1999) [Pubmed]
  3. Additional genes which result in an elevation of acetylcholine levels by mutations in Caenorhabditis elegans. Hosono, R., Kamiya, Y. Neurosci. Lett. (1991) [Pubmed]
  4. Amphid defective mutant of Caenorhabditis elegans. De Riso, L., Ristoratore, F., Sebastiano, M., Bazzicalupo, P. Genetica (1994) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities