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Gene Review

Mcpt8  -  mast cell protease 8

Mus musculus

Synonyms: BB139338, MMCP-8, Mast cell protease 8, mMCP-8
 
 
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Disease relevance of Mcpt8

  • Isolation of IgE receptor-positive cells from spleen shortly after peak parasitemia led to a prominent enrichment of MMCP-8-expressing cells [1].
 

High impact information on Mcpt8

  • Interestingly, the IC-2 cell line was shown to express several markers for immature mast cells and in addition MMCP-8, a serine protease which may represent a marker for mouse basophils [2].
  • MMCP-8, the first lineage-specific differentiation marker for mouse basophils. Elevated numbers of potent IL-4-producing and MMCP-8-positive cells in spleens of malaria-infected mice [1].
  • A comparative analysis of the aa sequence of MMCP-8 with other hematopoietic serine proteases shows that it is more closely related to cathepsin G and T cell granzymes than to the MC chymases [3].
  • Northern blot analysis of rodent hematopoietic cell lines revealed high levels of MMCP-8 mRNA in a mouse connective tissue MC-like tumor line [3].
  • The MMCP-8 mRNA contains an open reading frame of 247 amino acids (aa), divided into a signal sequence of 18 aa followed by a 2-aa activation peptide (Gly-Glu) and a mature protease of 227 aa [3].
 

Biological context of Mcpt8

 

Anatomical context of Mcpt8

  • Using a recently developed PCR-based strategy, a cDNA encoding a novel mouse mast cell (MC) serine protease (MMCP-8) was isolated and characterized [3].
 

Other interactions of Mcpt8

References

  1. MMCP-8, the first lineage-specific differentiation marker for mouse basophils. Elevated numbers of potent IL-4-producing and MMCP-8-positive cells in spleens of malaria-infected mice. Poorafshar, M., Helmby, H., Troye-Blomberg, M., Hellman, L. Eur. J. Immunol. (2000) [Pubmed]
  2. Murine mast cell lines as indicators of early events in mast cell and basophil development. Lunderius, C., Xiang, Z., Nilsson, G., Hellman, L. Eur. J. Immunol. (2000) [Pubmed]
  3. Characterization of mouse mast cell protease-8, the first member of a novel subfamily of mouse mast cell serine proteases, distinct from both the classical chymases and tryptases. Lützelschwab, C., Huang, M.R., Kullberg, M.C., Aveskogh, M., Hellman, L. Eur. J. Immunol. (1998) [Pubmed]
  4. Granzyme-like sequences in bony fish shed light on the emergence of hematopoietic serine proteases during vertebrate evolution. Wernersson, S., Reimer, J.M., Poorafshar, M., Karlson, U., Wermenstam, N., Bengtén, E., Wilson, M., Pilström, L., Hellman, L. Dev. Comp. Immunol. (2006) [Pubmed]
 
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