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Gene Review:

sys-1 - Protein SYS-1

Caenorhabditis elegans

Siegfried, K.R. et al., Asahina, M. et al., Miskowski, J. et al.

Asahina, Valenta, Silhankova, Korinek, Jindra,

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High impact information on sys-1

We conclude that the primary role of sys-1 is to establish the shape and polarity of the hermaphrodite gonad [1].
Therefore, sys-1 is a dose-sensitive locus and may function together with pop-1 to control Z1/Z4 asymmetry [2].
We find that sys-1 is haplo-insufficient for gonadogenesis defects and that sys-1 and pop-1 mutants display a strong genetic interaction in double heterozygotes [2].
NHR-25 knockdown restores DTC formation and fertility in pop-1 and sys-1 mutants, suggesting that a balance between NHR-25 and beta-catenin pathway activities is required to establish both proximal and distal fates [3].

References

The sys-1 gene and sexual dimorphism during gonadogenesis in Caenorhabditis elegans. Miskowski, J., Li, Y., Kimble, J. Dev. Biol. (2001) [Pubmed]
The sys-1 and sys-3 genes cooperate with Wnt signaling to establish the proximal-distal axis of the Caenorhabditis elegans gonad. Siegfried, K.R., Kidd, A.R., Chesney, M.A., Kimble, J. Genetics (2004) [Pubmed]
Crosstalk between a nuclear receptor and beta-catenin signaling decides cell fates in the C. elegans somatic gonad. Asahina, M., Valenta, T., Silhankova, M., Korinek, V., Jindra, M. Dev. Cell (2006) [Pubmed]

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