Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

hmr-1 - Protein HMR-1

Caenorhabditis elegans

Pettitt, J. et al., Bruggeman, L.A. et al., Simske, J.S. et al.

Pettitt, Cox, Broadbent, Flett, Hardin, Simske, Köppen, Sims, Hodgkin, Yonkof, Hardin,

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High impact information on cadherin

Here, we show that VAB-9 requires HMR-1/cadherin for localization to the cell membrane, and both HMP-1/alpha-catenin and HMP-2/beta-catenin for maintaining its distribution at the cell junction [1].
Associated with failed elongation is the detachment of actin bundles from epidermal adherens junctions and failure to maintain cadherin in adherens junctions [2].
Similar to other p120ctn family members, JAC-1 binds the JMD of the classical cadherin HMR-1, and GFP-tagged JAC-1 localizes to adherens junctions in an HMR-1-dependent manner [2].
In undifferentiated cultured podocytes, TM4SF10 localized to the perinuclear region and translocated to the cell membrane after Cadherin appearance at cell-cell contacts [3].

References

The cell junction protein VAB-9 regulates adhesion and epidermal morphology in C. elegans. Simske, J.S., Köppen, M., Sims, P., Hodgkin, J., Yonkof, A., Hardin, J. Nat. Cell Biol. (2003) [Pubmed]
The Caenorhabditis elegans p120 catenin homologue, JAC-1, modulates cadherin-catenin function during epidermal morphogenesis. Pettitt, J., Cox, E.A., Broadbent, I.D., Flett, A., Hardin, J. J. Cell Biol. (2003) [Pubmed]
Expression of TM4SF10, a Claudin/EMP/PMP22 family cell junction protein, during mouse kidney development and podocyte differentiation. Bruggeman, L.A., Martinka, S., Simske, J.S. Dev. Dyn. (2007) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

AgaP_AGAP009726	Anopheles gambiae str. PEST
LOC556807	Danio rerio
CadN	Drosophila melanogaster
LOC427547	Gallus gallus
LOC100493382	Xenopus (Silurana) tropicalis

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