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Gene Review

Mllt4  -  myeloid/lymphoid or mixed-lineage leukemia...

Mus musculus

Synonyms: 5033403D15Rik, AF6, Af-6, Af6, Afadin, ...
 
 
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Disease relevance of Mllt4

  • We studied here a role of the interaction of nectin-1alpha with afadin in entry and/or cell-cell spread of HSV-1 [1].
  • Requirement of interaction of nectin-1alpha/HveC with afadin for efficient cell-cell spread of herpes simplex virus type 1 [1].
  • Of the five MAbs, three (AB9, AF6 and AG6) recognized the IHNV G protein, and the other two (AB7 and BC2) recognized the 90 kDa protein [2].
 

High impact information on Mllt4

 

Biological context of Mllt4

  • Afadin: A key molecule essential for structural organization of cell-cell junctions of polarized epithelia during embryogenesis [5].
  • Nectins are Ca2+-independent immunoglobulin-like cell adhesion molecules connected to the actin cytoskeleton through afadin [6].
  • Here, we examined the cellular localization of nectins and afadin throughout primitive streak, neural plate, and early organogenesis stages of mouse development [6].
  • As cell-cell junctions are important in morphogenesis, we generated a null mutation in the murine Af6 locus to test the hypothesis that lack of AF-6 function would cause epithelial abnormalities [7].
  • However, nectin-2alpha-DeltaC showed cis dimerization and trans interaction, both of which did not require the interaction of nectin-2alpha with afadin [8].
 

Anatomical context of Mllt4

 

Associations of Mllt4 with chemical compounds

  • PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor [10].
 

Physical interactions of Mllt4

  • This recruitment was dependent on the C-terminal PDZ domain-binding motif of nectin-1 which is necessary for the binding of afadin, suggesting that nectins recruit S-SCAM through afadin [11].
  • The nectin-afadin complex is involved in PDGF-induced cell survival, at least through the PI3K-Akt signaling pathway [12].
 

Other interactions of Mllt4

 

Analytical, diagnostic and therapeutic context of Mllt4

References

  1. Requirement of interaction of nectin-1alpha/HveC with afadin for efficient cell-cell spread of herpes simplex virus type 1. Sakisaka, T., Taniguchi, T., Nakanishi, H., Takahashi, K., Miyahara, M., Ikeda, W., Yokoyama, S., Peng, Y.F., Yamanishi, K., Takai, Y. J. Virol. (2001) [Pubmed]
  2. Monoclonal antibodies raised against infectious haematopoietic necrosis virus (IHNV) G protein and a cellular 90 kDa protein neutralize IHNV infection in vitro. Lee, J.Y., Cho, W.J., Do, J.W., Kim, H.J., Park, J.W., Park, M.A., Sohn, S.G., Jeong, G., Hah, Y.C. J. Gen. Virol. (1996) [Pubmed]
  3. Nectin: an adhesion molecule involved in formation of synapses. Mizoguchi, A., Nakanishi, H., Kimura, K., Matsubara, K., Ozaki-Kuroda, K., Katata, T., Honda, T., Kiyohara, Y., Heo, K., Higashi, M., Tsutsumi, T., Sonoda, S., Ide, C., Takai, Y. J. Cell Biol. (2002) [Pubmed]
  4. Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with Afadin, a PDZ domain-containing protein. Takahashi, K., Nakanishi, H., Miyahara, M., Mandai, K., Satoh, K., Satoh, A., Nishioka, H., Aoki, J., Nomoto, A., Mizoguchi, A., Takai, Y. J. Cell Biol. (1999) [Pubmed]
  5. Afadin: A key molecule essential for structural organization of cell-cell junctions of polarized epithelia during embryogenesis. Ikeda, W., Nakanishi, H., Miyoshi, J., Mandai, K., Ishizaki, H., Tanaka, M., Togawa, A., Takahashi, K., Nishioka, H., Yoshida, H., Mizoguchi, A., Nishikawa, S., Takai, Y. J. Cell Biol. (1999) [Pubmed]
  6. Expression patterns of nectins and afadin during epithelial remodeling in the mouse embryo. Okabe, N., Ozaki-Kuroda, K., Nakanishi, H., Shimizu, K., Takai, Y. Dev. Dyn. (2004) [Pubmed]
  7. Absence of the tight junctional protein AF-6 disrupts epithelial cell-cell junctions and cell polarity during mouse development. Zhadanov, A.B., Provance, D.W., Speer, C.A., Coffin, J.D., Goss, D., Blixt, J.A., Reichert, C.M., Mercer, J.A. Curr. Biol. (1999) [Pubmed]
  8. Interaction of nectin with afadin is necessary for its clustering at cell-cell contact sites but not for its cis dimerization or trans interaction. Miyahara, M., Nakanishi, H., Takahashi, K., Satoh-Horikawa, K., Tachibana, K., Takai, Y. J. Biol. Chem. (2000) [Pubmed]
  9. Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse. Takekuni, K., Ikeda, W., Fujito, T., Morimoto, K., Takeuchi, M., Monden, M., Takai, Y. J. Biol. Chem. (2003) [Pubmed]
  10. PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor. Hock, B., Böhme, B., Karn, T., Yamamoto, T., Kaibuchi, K., Holtrich, U., Holland, S., Pawson, T., Rübsamen-Waigmann, H., Strebhardt, K. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  11. Nectin-dependent localization of synaptic scaffolding molecule (S-SCAM) at the puncta adherentia junctions formed between the mossy fibre terminals and the dendrites of pyramidal cells in the CA3 area of the mouse hippocampus. Yamada, A., Irie, K., Deguchi-Tawarada, M., Ohtsuka, T., Takai, Y. Genes Cells (2003) [Pubmed]
  12. Involvement of the nectin-afadin complex in PDGF-induced cell survival. Kanzaki, N., Ogita, H., Komura, H., Ozaki, M., Sakamoto, Y., Majima, T., Ijuin, T., Takenawa, T., Takai, Y. J. Cell. Sci. (2008) [Pubmed]
  13. A close correlation in the expression patterns of Af-6 and Usp9x in Sertoli and granulosa cells of mouse testis and ovary. Sato, T., Kanai, Y., Noma, T., Kanai-Azuma, M., Taya, S., Matsui, T., Ishii, M., Kawakami, H., Kurohmaru, M., Kaibuchi, K., Wood, S.A., Hayashi, Y. Reproduction (2004) [Pubmed]
  14. Nectin couples cell-cell adhesion and the actin scaffold at heterotypic testicular junctions. Ozaki-Kuroda, K., Nakanishi, H., Ohta, H., Tanaka, H., Kurihara, H., Mueller, S., Irie, K., Ikeda, W., Sakai, T., Wimmer, E., Nishimune, Y., Takai, Y. Curr. Biol. (2002) [Pubmed]
  15. Involvement of LMO7 in the association of two cell-cell adhesion molecules, nectin and E-cadherin, through afadin and alpha-actinin in epithelial cells. Ooshio, T., Irie, K., Morimoto, K., Fukuhara, A., Imai, T., Takai, Y. J. Biol. Chem. (2004) [Pubmed]
 
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