Disease relevance of Trpm1

• Within the set of human primary cutaneous melanomas examined, melastatin expression appeared to correlate inversely with tumor thickness [1].
• Melastatin transcripts were not detected in melanoma metastases [1].
• This analysis identified a novel gene, termed melastatin, that is expressed at high levels in poorly metastatic variants of B16 melanoma and at much reduced levels in highly metastatic B16 variants [1].

High impact information on Trpm1

• Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis [1].
• The promoter region of Mlsn1 contains four potential microphthalmia binding sites including an M box, a transcriptional regulatory element unique to genes with a restricted melanocytic expression pattern [2].
• The mouse melastatin gene contains 27 exons and spans at least 58 kb of genomic DNA [2].
• Although expression patterns and chromosomal localization in the mouse are consistent with involvement of melastatin mutations in the mouse ruby-eye-2 defect, congenic analysis showed genetic segregation of the two loci [2].
• The TRP-melastatin (TRPM) subfamily includes the putative tumor-suppressor melastatin, which was originally found as a down-regulated protein in melanoma tumor cell lines [3].

Biological context of Trpm1

• Expression and Up-regulation of alternatively spliced transcripts of melastatin, a melanoma metastasis-related gene, in human melanoma cells [4].
• Using biochemical, pharmacological, and genetic tools, the role of transient receptor potential membrane melastatin 7 (TRPM7) cation channel in VSMC Mg2+ homeostasis was evaluated [5].

Anatomical context of Trpm1

• Transient receptor potential melastatin 7 ion channels regulate magnesium homeostasis in vascular smooth muscle cells: role of angiotensin II [5].

References