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Gene Review

Ndst2  -  N-deacetylase/N-sulfotransferase (heparan...

Mus musculus

Synonyms: Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2, Glucosaminyl N-deacetylase/N-sulfotransferase 2, Hsst2, Mndns, N-HSST 2, ...
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Disease relevance of Ndst2


High impact information on Ndst2

  • These NDST-2-deficient mice are viable and fertile but have fewer connective-tissue-type mast cells; these cells have an altered morphology and contain severely reduced amounts of histamine and mast-cell proteases [3].
  • Here we report that mice carrying a targeted disruption of the gene encoding NDST-2 are unable to synthesize sulphated heparin [3].
  • GA binding protein (GABP) bound the GGAA motif and increased the amount of NDST-2 transcript [4].
  • Heparan sulfate synthesized by mouse embryonic stem cells deficient in NDST1 and NDST2 is 6-O-sulfated but contains no N-sulfate groups [5].
  • Using a high throughput heparan sulfate (HS) isolation and characterization protocol, we have analyzed HS structure in several tissues from mice/mouse embryos deficient in HS biosynthesis enzymes (N-deacetylase/N-sulfotransferase (NDST)-1, NDST-2, and C5-epimerase, respectively) and in mice lacking syndecan-1 [6].

Biological context of Ndst2


Anatomical context of Ndst2


Associations of Ndst2 with chemical compounds

  • The corresponding NDST-2-/- cells produced highly sulphated CS only [10].

Enzymatic interactions of Ndst2


Regulatory relationships of Ndst2

  • Plasminogen was activated to plasmin at an apparently higher rate in peritoneal cells from NDST-2 null mice than in the normal controls [12].

Other interactions of Ndst2


Analytical, diagnostic and therapeutic context of Ndst2


  1. Neurogenic inflammation in mice deficient in heparin-synthesizing enzyme. Karlsen, T.V., Iversen, V.V., Forsberg, E., Kjellén, L., Reed, R.K., Gjerde, E.A. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
  2. Inhibition of thrombosis in melanoma allografts in mice by endogenous mast cell heparin. Samoszuk, M., Corwin, M., Yu, H., Wang, J., Nalcioglu, O., Su, M.Y. Thromb. Haemost. (2003) [Pubmed]
  3. Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme. Forsberg, E., Pejler, G., Ringvall, M., Lunderius, C., Tomasini-Johansson, B., Kusche-Gullberg, M., Eriksson, I., Ledin, J., Hellman, L., Kjellén, L. Nature (1999) [Pubmed]
  4. Inhibitory effect of the mi transcription factor encoded by the mutant mi allele on GA binding protein-mediated transcript expression in mouse mast cells. Morii, E., Ogihara, H., Oboki, K., Sawa, C., Sakuma, T., Nomura, S., Esko, J.D., Handa, H., Kitamura, Y. Blood (2001) [Pubmed]
  5. Heparan sulfate synthesized by mouse embryonic stem cells deficient in NDST1 and NDST2 is 6-O-sulfated but contains no N-sulfate groups. Holmborn, K., Ledin, J., Smeds, E., Eriksson, I., Kusche-Gullberg, M., Kjellén, L. J. Biol. Chem. (2004) [Pubmed]
  6. Heparan sulfate structure in mice with genetically modified heparan sulfate production. Ledin, J., Staatz, W., Li, J.P., Götte, M., Selleck, S., Kjellén, L., Spillmann, D. J. Biol. Chem. (2004) [Pubmed]
  7. Disturbed Ca2+ kinetics in N-deacetylase/N-sulfotransferase-1 defective myotubes. Jenniskens, G.J., Ringvall, M., Koopman, W.J., Ledin, J., Kjellén, L., Willems, P.H., Forsberg, E., Veerkamp, J.H., van Kuppevelt, T.H. J. Cell. Sci. (2003) [Pubmed]
  8. Acceleration of tumor growth and peri-tumoral blood clotting by imatinib mesylate (Gleevec). Samoszuk, M., Corwin, M.A. Int. J. Cancer (2003) [Pubmed]
  9. Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. Aikawa, J., Esko, J.D. J. Biol. Chem. (1999) [Pubmed]
  10. Altered storage of proteases in mast cells from mice lacking heparin: a possible role for heparin in carboxypeptidase A processing. Henningsson, F., Ledin, J., Lunderius, C., Wilén, M., Hellman, L., Pejler, G. Biol. Chem. (2002) [Pubmed]
  11. Altered processing of fibronectin in mice lacking heparin. a role for heparin-dependent mast cell chymase in fibronectin degradation. Tchougounova, E., Forsberg, E., Angelborg, G., Kjéllen, L., Pejler, G. J. Biol. Chem. (2001) [Pubmed]
  12. Regulation of extravascular coagulation and fibrinolysis by heparin-dependent mast cell chymase. Tchougounova, E., Pejler, G. FASEB J. (2001) [Pubmed]
  13. Regulated translation of heparan sulfate N-acetylglucosamine N-deacetylase/n-sulfotransferase isozymes by structured 5'-untranslated regions and internal ribosome entry sites. Grobe, K., Esko, J.D. J. Biol. Chem. (2002) [Pubmed]
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