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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

pyr-1  -  Protein PYR-1

Caenorhabditis elegans

 
 
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High impact information on pyr-1

  • We have identified the spontaneous mutant pyr-1(cu8) exhibiting defective pharyngeal isthmus elongation, cytoskeletal organization defects, and maternal effect lethality. pyr-1 encodes CAD, a trifunctional enzyme required for de novo pyrimidine synthesis, and pyr-1(cu8) mutants are rescued by supplying exogenous pyrimidines [1].
  • The enhancer of rudimentary gene, e(r), in Drosophila melanogaster encodes a protein, ER, whose function has been implicated in pyrimidine biosynthesis and the cell cycle (Wojcik et al. (1994) Genetics 138, 1163-1170) [2].

References

  1. C. elegans pharyngeal morphogenesis requires both de novo synthesis of pyrimidines and synthesis of heparan sulfate proteoglycans. Franks, D.M., Izumikawa, T., Kitagawa, H., Sugahara, K., Okkema, P.G. Dev. Biol. (2006) [Pubmed]
  2. The putative cell cycle gene, enhancer of rudimentary, encodes a highly conserved protein found in plants and animals. Gelsthorpe, M., Pulumati, M., McCallum, C., Dang-Vu, K., Tsubota, S.I. Gene (1997) [Pubmed]
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