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Gene Review:

let-19 - Protein LET-19

Caenorhabditis elegans

Wang, J.C. et al., Yoda, A. et al.

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High impact information on let-19

We found that the let-19 and dpy-22 mutants have defects in their T-cell lineage, and lineage analyses showed that the defects were caused by disruption in the asymmetry of the T-cell division [1].
Furthermore, we found that the let-19 and dpy-22 mutants were defective in the fusion of the Pn.p cell, a process that is regulated by bar-1/beta-catenin [1].
The Caenorhabditis elegans ortholog of TRAP240, CeTRAP240/let-19, selectively modulates gene expression and is essential for embryogenesis [2].
Using RNA interference, we found that reduced expression of CeTRAP240/let-19 displayed a high penetrance of embryonic lethality in F1 progeny; animals that escaped embryonic arrest showed mutant phenotypes such as burst vulva and molting defects [2].
CeTRAP240/let-19 appeared to affect specific genes, as CeTRAP240/let-19(RNAi) led to selectively reduced expression of a subset of reporter genes examined [2].

References

Components of the transcriptional Mediator complex are required for asymmetric cell division in C. elegans. Yoda, A., Kouike, H., Okano, H., Sawa, H. Development (2005) [Pubmed]
The Caenorhabditis elegans ortholog of TRAP240, CeTRAP240/let-19, selectively modulates gene expression and is essential for embryogenesis. Wang, J.C., Walker, A., Blackwell, T.K., Yamamoto, K.R. J. Biol. Chem. (2004) [Pubmed]

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