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Gene Review:

rha-1 - Protein RHA-1

Caenorhabditis elegans

Navarro, R.E. et al., Walstrom, K.M. et al., Dalmay, T. et al., Tijsterman, M. et al.

Walstrom, Schmidt, Bean, Kelly,

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Disease relevance of rha-1

In Caenorhabditis elegans, lack of the conserved germline RNA helicase CGH-1 causes infertility and excessive levels of physiological germline apoptosis, a process that normally claims about half of all developing oocytes [1].

High impact information on rha-1

SDE3 encodes an RNA helicase required for post-transcriptional gene silencing in Arabidopsis [2].
RNA helicase A is important for germline transcriptional control, proliferation, and meiosis in C. elegans [3].
RNA helicase MUT-14-dependent gene silencing triggered in C. elegans by short antisense RNAs [4].

References

Requirement for P granules and meiosis for accumulation of the germline RNA helicase CGH-1. Navarro, R.E., Blackwell, T.K. Genesis (2005) [Pubmed]
SDE3 encodes an RNA helicase required for post-transcriptional gene silencing in Arabidopsis. Dalmay, T., Horsefield, R., Braunstein, T.H., Baulcombe, D.C. EMBO J. (2001) [Pubmed]
RNA helicase A is important for germline transcriptional control, proliferation, and meiosis in C. elegans. Walstrom, K.M., Schmidt, D., Bean, C.J., Kelly, W.G. Mech. Dev. (2005) [Pubmed]
RNA helicase MUT-14-dependent gene silencing triggered in C. elegans by short antisense RNAs. Tijsterman, M., Ketting, R.F., Okihara, K.L., Sijen, T., Plasterk, R.H. Science (2002) [Pubmed]

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