Disease relevance of Mov10

• The Mov-7 and Mov-10 substrains of mice were used, each of which carries a Moloney murine leukemia provirus with mutations in the coding regions at nonidentical positions [1].
• When postnatal Mov-7/Mov-10 F1 mice were treated with the drug, infectious virus was generated efficiently and resulted in virus spread and viremia in all animals by 3 weeks of age [1].
• The Mov-10 locus was expressed in a variety of cell types, including embryonal carcinoma and embryonic stem cells [2].

High impact information on Mov10

• The Mov-10 mouse strain was derived by infection of preimplantation embryos with the Moloney murine leukemia virus and carries one copy of the provirus in its germ line [2].
• The results suggest that the Mov-10 locus has an important function in development and/or control of cell proliferation [2].
• High levels of Mov-10 transcripts were also found at different stages of embryonal development and in the testes and thymus of adult animals [2].
• Restriction enzyme analysis revealed no major deletions or insertions in the proviral genomes of the Mov-2 and Mov-10 locus [3].
• The specific infectivity, however, was very low and 3T3 cells transfected with the Mov-2 or Mov-10 clone did not produce infectious virus [3].

Biological context of Mov10

• The Mov-10-specific probe detects an EcoRI-specific restriction fragment length polymorphism, which can make this probe a useful genetic marker [4].
• The results suggest that the M-MuLV integrated at the Mov-2 and Mov-10 locus carry a mutation which prevents synthesis of infectious virus but permits XC plaque induction by partial genome expression or synthesis of non-infectious particles [3].

Other interactions of Mov10

• The M-MuLV proviruses with flanking mouse sequences corresponding to the Mov-2 and Mov-10 locus, respectively, were molecularly cloned [3].

References