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Gene Review:

ref-1 - Protein REF-1

Caenorhabditis elegans

Ross, J.M. et al., Lanjuin, A. et al., Alper, S. et al.

Alper, Kenyon,

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High impact information on ref-1

Here we identify a gene, ref-1, that regulates the hermaphrodite Pn.p cell fusion pattern largely by regulating MAB-5 activity in these cells [1].
However, in ref-1 mutants, while the ectopically generated neurons exhibit gene expression profiles characteristic of neurons on the left, they are present only on the right side [2].
Mutations in ref-1 restore lin-32::gfp expression and normal V ray development to mab-3 mutants, suggesting that ref-1 is the primary target of MAB-3 in the V ray lineage [3].
Here we show that MAB-3 promotes expression of the proneural protein LIN-32 in V ray precursors by transcriptional repression of ref-1, a member of the Hes family of neurogenic factors [3].

References

REF-1, a protein with two bHLH domains, alters the pattern of cell fusion in C. elegans by regulating Hox protein activity. Alper, S., Kenyon, C. Development (2001) [Pubmed]
Regulation of neuronal lineage decisions by the HES-related bHLH protein REF-1. Lanjuin, A., Claggett, J., Shibuya, M., Hunter, C.P., Sengupta, P. Dev. Biol. (2006) [Pubmed]
The DM domain protein MAB-3 promotes sex-specific neurogenesis in C. elegans by regulating bHLH proteins. Ross, J.M., Kalis, A.K., Murphy, M.W., Zarkower, D. Dev. Cell (2005) [Pubmed]

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